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SARS-COV-2变体出现对单克隆和血清来源的多克隆抗体的抗性
作者:小柯机器人 发布时间:2021/3/7 22:14:44

2021年3月4日,美国华盛顿大学医学院Michael S. Diamond等研究人员合作在《自然—医学》杂志发表论文,揭示SARS-COV-2变体对单克隆和血清来源的多克隆抗体的抗性。

通过使用单克隆抗体(mAb)、动物免疫血清、人类康复期血清和来自BNT162B2 mRNA疫苗接种者的血清,研究人员报告了抗体中和效应对不同SARS-COV-2变体的影响。许多高度中和的mAb识别受体结合结构域或N-末端结构域,而大多数康复期血清和mRNA疫苗诱导的免疫血清对含有E484K突刺突变的抑制活性降低。

由于这些抗体对新兴病毒株的中和活性降低,后续的疗法可能需要针对高度保守区域的鸡尾酒抗体疗法、提高mAb效力或调整疫苗靶向的突刺序列。 

据悉,SARS-COV-2导致全球Covid-19大流行。快速扩散的SARS-COV-2变体可能会影响刚研发的抗体和疫苗。

附:英文原文

Title: Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies

Author: Rita E. Chen, Xianwen Zhang, James Brett Case, Emma S. Winkler, Yang Liu, Laura A. VanBlargan, Jianying Liu, John M. Errico, Xuping Xie, Naveenchandra Suryadevara, Pavlo Gilchuk, Seth J. Zost, Stephen Tahan, Lindsay Droit, Jackson S. Turner, Wooseob Kim, Aaron J. Schmitz, Mahima Thapa, David Wang, Adrianus C. M. Boon, Rachel M. Presti, Jane A. OHalloran, Alfred H. J. Kim, Parakkal Deepak, Dora Pinto, Daved H. Fremont, James E. Crowe, Davide Corti, Herbert W. Virgin, Ali H. Ellebedy, Pei-Yong Shi, Michael S. Diamond

Issue&Volume: 2021-03-04

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the global COVID-19 pandemic. Rapidly spreading SARS-CoV-2 variants may jeopardize newly introduced antibody and vaccine countermeasures. Here, using monoclonal antibodies (mAbs), animal immune sera, human convalescent sera and human sera from recipients of the BNT162b2 mRNA vaccine, we report the impact on antibody neutralization of a panel of authentic SARS-CoV-2 variants including a B.1.1.7 isolate, chimeric strains with South African or Brazilian spike genes and isogenic recombinant viral variants. Many highly neutralizing mAbs engaging the receptor-binding domain or N-terminal domain and most convalescent sera and mRNA vaccine-induced immune sera showed reduced inhibitory activity against viruses containing an E484K spike mutation. 

DOI: 10.1038/s41591-021-01294-w

Source: https://www.nature.com/articles/s41591-021-01294-w

期刊信息

Nature Medicine:《自然—医学》,创刊于1995年。隶属于施普林格·自然出版集团,最新IF:30.641
官方网址:https://www.nature.com/nm/
投稿链接:https://mts-nmed.nature.com/cgi-bin/main.plex