德国哥廷根大学Lutz Ackermann团队揭示了弱O配位Rhoda电催化双金属C-H氧化策略。 相关研究成果发表在2021年3月2日出版的《德国应用化学》。

用双金属电催化方法建立了弱O配位酰胺和酮对铑电催化的芳烃C-H氧化反应。同样地，通过明智地选择电流，可以选择性地获得不同的二氢恶嗪酮，从而实现双重C–H功能化。

通过实验、质谱和循环伏安分析进行了详细的机理研究，为双金属铑催化歧管的电氧化诱导C-H活化提供了支持。

附：英文原文

Title: Rhoda‐Electrocatalyzed Bimetallic C–H Oxygenation by Weak O‐Coordination

Author: Xuefeng Tan, Leonardo Massignan, Xiaoyan Hou, Johanna Frey, Jo, Masoom Nasiha Hussain, Lutz Ackermann

Issue&Volume: 2021-03-02

Abstract: Rhodium‐electrocatalyzed arene C–H oxygenation by weakly  O‐  coordinating amides and ketones have been established by bimetallic electrocatalysis. Likewise, diverse dihydrooxazinones were selectively accessed by the judicious choice of current, enabling twofold C–H functionalization. Detailed mechanistic studies by experiment, mass spectroscopy and cyclovoltammetric analysis provided support for an unprecedented electrooxidation‐induced C–H activation by a bimetallic rhodium catalysis manifold.

DOI: 10.1002/anie.202017359

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202017359