中国科学院长春应用化学研究所刘凯课题组近日发现了一种具有强韧和可变粘附特性的人工相转变水下生物胶。2021年3月1日，国际知名学术期刊《德国应用化学》发表了这一成果。

在该研究中，通过超分子组装和合理的蛋白质设计，课题组人员利用重组蛋白和表面活性剂，制备了一种温度敏感型湿式生物粘合剂。该生物胶系统的机械性能可以通过热触发主动调控。在低温条件下，该生物胶的粘附强度仅为~ 50kpa。随着温度的升高，其强度可达600 kpa，明显强于其他同类生物材料。这可能是由于工程蛋白的热触发相变和凝聚物的形成，导致温度升高时增强的湿粘附能力。该策略在制造智能生物材料——例如新一代医用温敏贴片方面——具有广阔的前景。

据悉，在自然和人工系统中，复杂的凝聚行为使重要的湿粘附过程成为可能。然而，现有的合成凝聚层粘合剂湿粘合性能较为有限，且不具热响应性和生物可降解性，极大地阻碍了它们的转化应用。

附：英文原文

Title: An artificial phase‐transitional underwater bioglue with robust and switchable adhesion performance

Author: Lingling Xiao, Zili Wang, Yao Sun, Bo Li, Baiheng Wu, Chao Ma, Vladislav S. Petrovskii, Xinquan Gu, Dong Chen, Igor I. Potemkin, Andreas Herrmann, Hongjie Zhang, Kai Liu

Issue&Volume: 2021-03-01

Abstract: Complex coacervation enables important wet adhesion processes in natural and artificial systems. However, existed synthetic coacervate adhesives show limited wet adhesion properties, non‐thermoresponsiveness, and inferior biodegradability, greatly hampering their translations. Herein, by harnessing supramolecular assembly and rational protein design, we present a temperature‐sensitive wet bioadhesive fabricated through recombinant protein and surfactant. Mechanical performance of the bioglue system is actively tunable with thermal triggers. In cold condition, adhesion strength of the bioadhesive was only ~50 kPa. By increasing temperature, the strength presented up to 600 kPa, which is remarkably stronger than other biological counterparts. This is probably due to the thermally triggered phase transition of the engineered protein and the formation of coacervate, thus leading to the enhanced wet adhesion bonding. This strategy holds great promise for the fabrication of smart biomaterials such as new generation of thermo‐responsive patches for healthcare applications.

DOI: 10.1002/anie.202102158

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202102158