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胎盘超氧化物歧化酶3介导母亲运动对子代健康的益处
作者:小柯机器人 发布时间:2021/3/28 16:20:52

近日,美国哈佛医学院Laurie J. Goodyear、Joji Kusuyama等研究人员合作发现,胎盘超氧化物歧化酶3介导母亲运动对子代健康的益处。相关论文于2021年3月25日在线发表在《细胞—代谢》杂志上。

孕产妇饮食不良会增加后代肥胖和2型糖尿病的风险,从而使这些疾病的患病率不断增加。相反,研究人员发现母亲运动可以改善后代的代谢健康,并证明这是通过维生素D受体介导的胎盘超氧化物歧化酶3(SOD3)表达和分泌增加而发生的。

SOD3激活胎儿肝脏中的AMPK/TET信号轴,导致葡萄糖代谢基因启动子处的DNA去甲基化,增强肝脏功能,并改善葡萄糖耐量。在人类中,身体活跃的孕妇血清和胎盘中的SOD3上调。孕妇运动引起的胎盘来源的SOD3与后代肝脏之间交流为改善后代代谢健康提供了重要机制。这些发现可能促进新的治疗方法,从而限制代谢疾病的代系传播。 

附:英文原文

Title: Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health

Author: Joji Kusuyama, Ana Barbara Alves-Wagner, Royce H. Conlin, Nathan S. Makarewicz, Brent G. Albertson, Noah B. Prince, Shio Kobayashi, Chisayo Kozuka, Magnus Mller, Mette Bjerre, Jens Fuglsang, Emily Miele, Roeland J.W. Middelbeek, Yang Xiudong, Yang Xia, Léa Garneau, Jayonta Bhattacharjee, Céline Aguer, Mary Elizabeth Patti, Michael F. Hirshman, Niels Jessen, Toshihisa Hatta, Per Glud Ovesen, Kristi B. Adamo, Eva Nozik-Grayck, Laurie J. Goodyear

Issue&Volume: 2021-03-25

Abstract: Poor maternal diet increases the risk of obesity and type 2 diabetes in offspring,adding to the ever-increasing prevalence of these diseases. In contrast, we find thatmaternal exercise improves the metabolic health of offspring, and here, we demonstratethat this occurs through a vitamin D receptor-mediated increase in placental superoxidedismutase 3 (SOD3) expression and secretion. SOD3 activates an AMPK/TET signalingaxis in fetal offspring liver, resulting in DNA demethylation at the promoters ofglucose metabolic genes, enhancing liver function, and improving glucose tolerance.In humans, SOD3 is upregulated in serum and placenta from physically active pregnantwomen. The discovery of maternal exercise-induced cross talk between placenta-derivedSOD3 and offspring liver provides a central mechanism for improved offspring metabolichealth. These findings may lead to novel therapeutic approaches to limit the transmissionof metabolic disease to the next generation.

DOI: 10.1016/j.cmet.2021.03.004

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00111-X

期刊信息

Cell Metabolism:《细胞—代谢》,创刊于2005年。隶属于细胞出版社,最新IF:22.415
官方网址:https://www.cell.com/cell-metabolism/home
投稿链接:https://www.editorialmanager.com/cell-metabolism/default.aspx