斯洛伐克卫生部Martin Pavelka等研究人员揭示人群范围内快速抗原检测对SARS-CoV-2患病率的影响。相关论文于2021年3月23日在线发表在《科学》杂志上。

斯洛伐克在2020年底对SARS-CoV-2进行了多轮人群范围的快速抗原检测，同时还进行了一段时间的接触限制。研究人员发现，在接受两轮大规模测试的45个县中，一周内观察到的患病率降低了58％（95％CI：57-58％），这一估计值在调整多个潜在的混杂因素时仍然很可靠。

在进行大规模测试之前，根据流行病每天增长4.4％（1.1-6.9％）进行调整后，与未缓解增长情况相比，估计的患病率下降了70％（67-73％）。建模表明，这种下降不能仅通过感染控制措施来解释，而是需要对阳性家庭成员进行隔离和检疫。

附：英文原文

Title: The impact of population-wide rapid antigen testing on SARS-CoV-2 prevalence in Slovakia

Author: Martin Pavelka, Kevin Van-Zandvoort, Sam Abbott, Katharine Sherratt, Marek Majdan, CMMID COVID- working group, Intitút Zdravotnych Analyz, Pavol Jaruka, Marek Krají, Stefan Flasche, Sebastian Funk

Issue&Volume: 2021/03/23

Abstract: Slovakia conducted multiple rounds of population-wide rapid antigen testing for SARS-CoV-2 in late 2020, combined with a period of additional contact restrictions. Observed prevalence decreased by 58% (95% CI: 57-58%) within one week in the 45 counties that were subject to two rounds of mass testing, an estimate that remained robust when adjusting for multiple potential confounders. Adjusting for epidemic growth of 4.4% (1.1-6.9%) per day preceding the mass testing campaign, the estimated decrease in prevalence compared to a scenario of unmitigated growth was 70% (67-73%). Modelling indicated that this decrease could not be explained solely by infection control measures, but required the additional impact of isolation and quarantine of household members of those testing positive.

DOI: 10.1126/science.abf9648

Source: https://science.sciencemag.org/content/early/2021/03/22/science.abf9648