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肝动态平衡由中叶2区肝细胞所维持
作者:小柯机器人 发布时间:2021/2/28 18:40:04

美国德克萨斯大学西南医学中心Hao Zhu研究团队发现,肝动态平衡由中叶2区肝细胞所维持。相关论文于2021年2月26日发表在《科学》杂志上。

研究人员使用了14种小鼠命运映射谱系来系统地比较了肝细胞的不同子集。在稳态期间,来自门周围1区和中心周围3区的细胞数量减少,而来自小叶间2区的细胞数量增加。2区中的细胞可以避免常见的损伤,并且在中央和周围的损伤后也促进了细胞的再生。2区的重新填充是由IGFBP2-mTOR-CCND1信号轴来驱动的。

因此,肝小叶的不同区域表现出它们对肝细胞更新贡献的差异,并且2区是在稳态和再生过程中新肝细胞的重要来源。 

据悉,肝脏组织成几个区域,在这些区域中,肝细胞表达不同的代谢酶。负责肝脏重新繁殖和再生的最主要细胞仍然不确定,因为命运定位仅在少数肝细胞亚群上进行。

附:英文原文

Title: Liver homeostasis is maintained by midlobular zone 2 hepatocytes

Author: Yonglong Wei, Yunguan G. Wang, Yuemeng Jia, Lin Li, Jung Yoon, Shuyuan Zhang, Zixi Wang, Yu Zhang, Min Zhu, Tripti Sharma, Yu-Hsuan Lin, Meng-Hsiung Hsieh, Jeffrey H. Albrecht, Phuong T. Le, Clifford J. Rosen, Tao Wang, Hao Zhu

Issue&Volume: 2021/02/26

Abstract: The liver is organized into zones in which hepatocytes express different metabolic enzymes. The cells most responsible for liver repopulation and regeneration remain undefined, because fate mapping has only been performed on a few hepatocyte subsets. Here, 14 murine fate-mapping strains were used to systematically compare distinct subsets of hepatocytes. During homeostasis, cells from both periportal zone 1 and pericentral zone 3 contracted in number, whereas cells from midlobular zone 2 expanded in number. Cells within zone 2, which are sheltered from common injuries, also contributed to regeneration after pericentral and periportal injuries. Repopulation from zone 2 was driven by the insulin-like growth factor binding protein 2–mechanistic target of rapamycin–cyclin D1 (IGFBP2-mTOR-CCND1) axis. Therefore, different regions of the lobule exhibit differences in their contribution to hepatocyte turnover, and zone 2 is an important source of new hepatocytes during homeostasis and regeneration.

DOI: 10.1126/science.abb1625

Source: https://science.sciencemag.org/content/371/6532/eabb1625

期刊信息
Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037