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科学家鉴定出一种与人类高热病有关的新型正内罗病毒
作者:小柯机器人 发布时间:2021/2/20 16:57:42

佛山大学Quan Liu等研究人员合作鉴定出一种与人类高热病有关的新型正内罗病毒 。2021年2月18日,国际知名学术期刊《自然—医学》在线发表了这一成果。

研究人员表示,正内罗病毒属(Orthonairovirus)是内罗病毒科(Nairoviridae)家族的一部分,包括重要的扁虱传播病原体克里米亚-刚果出血热病毒和内罗毕绵羊病病毒,以及在扁虱、鸟类和哺乳动物中发现的其他许多特征较差的病毒。

研究人员从据报道被扁虱叮咬的患者中鉴定出一种新的正内罗病毒属,Songling病毒(SGLV)。SGLV与正内罗病毒属具有相似的基因组和形态学特征,并且在系统发育上在内罗病毒科的Tamdy orthonairovirus中形成了独特的进化枝。分离的SGLV能够在体外诱导人肝癌细胞中的细胞病变作用。

在2017年至2018年之间分析的42例住院患者中确认了SGLV感染,主要临床表现为头痛、发烧、抑郁、疲劳和头晕。超过三分之二(69%)的患者在急性期产生了病毒特异性抗体反应。因此,这些结果表明,这种新发现的正内罗病毒与人类高热病有关。 

附:英文原文

Title: Identification of a new orthonairovirus associated with human febrile illness

Author: Jun Ma, Xiao-Long Lv, Xu Zhang, Shu-Zheng Han, Ze-Dong Wang, Liang Li, He-Ting Sun, Li-Xin Ma, Zheng-Lei Cheng, Jian-Wei Shao, Chen Chen, Ying-Hua Zhao, Liyan Sui, Lin-Na Liu, Jun Qian, Wei Wang, Quan Liu

Issue&Volume: 2021-02-18

Abstract: The genus Orthonairovirus, which is part of the family Nairoviridae, includes the important tick-transmitted pathogens Crimean–Congo hemorrhagic fever virus and Nairobi sheep disease virus, as well as many other poorly characterized viruses found in ticks, birds and mammals1,2. In this study, we identified a new orthonairovirus, Songling virus (SGLV), from patients who reported being bitten by ticks. SGLV shared similar genomic and morphological features with orthonairoviruses and phylogenetically formed a unique clade in Tamdy orthonairovirus of the Nairoviridae family. The isolated SGLV induced cytopathic effects in human hepatoma cells in vitro. SGLV infection was confirmed in 42 hospitalized patients analyzed between 2017 and 2018, with the main clinical manifestations being headache, fever, depression, fatigue and dizziness. More than two-thirds (69%) of patients generated virus-specific antibody responses in the acute phase. 

DOI: 10.1038/s41591-020-01228-y

Source: https://www.nature.com/articles/s41591-020-01228-y

期刊信息

Nature Medicine:《自然—医学》,创刊于1995年。隶属于施普林格·自然出版集团,最新IF:30.641
官方网址:https://www.nature.com/nm/
投稿链接:https://mts-nmed.nature.com/cgi-bin/main.plex