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低频刺激可增强中风后的协同放电和敏捷度
作者:小柯机器人 发布时间:2021/2/20 11:17:26

美国加州大学Karunesh Ganguly研究组近日取得一项新成果。他们揭示低频刺激可增强中风后的协同放电和敏捷度。相关论文于2021年2月10日发表在《细胞》杂志上。

他们测试了从中风恢复的非人类灵长类动物中的低频硬膜外交流电刺激(ACS)如何与病灶周围皮层中的任务相关活动相互作用并影响抓紧力。他们发现ACS增加了与任务相关的协同放电并提高了灵活性。使用神经网络模型,他们发现模拟ACS可以驱动协同放电并增强神经活动通过网络部分连通性而导致神经活动的传播,而连接性受损的现象提示了一种机制,可以将增加的协同放电与增强的敏捷性联系起来。

总之,他们的结果表明,ACS可恢复受损网络中的神经处理并改善中风后的敏捷性。更广泛地说,这些结果证明了优化刺激以靶向神经动力学的方法。

据了解,电刺激是调节大脑网络的潜在工具。然而,尚不清楚刺激如何与行为基础的神经模式相互作用。

附:英文原文

Title: Low-frequency stimulation enhances ensemble co-firing and dexterity after stroke

Author: Preeya Khanna, Douglas Totten, Lisa Novik, Jeffrey Roberts, Robert J. Morecraft, Karunesh Ganguly

Issue&Volume: 2021/02/18

Abstract: Electrical stimulation is a promising tool for modulating brain networks. However,it is unclear how stimulation interacts with neural patterns underlying behavior.Specifically, how might external stimulation that is not sensitive to the state ofongoing neural dynamics reliably augment neural processing and improve function Here,we tested how low-frequency epidural alternating current stimulation (ACS) in non-humanprimates recovering from stroke interacted with task-related activity in perilesionalcortex and affected grasping. We found that ACS increased co-firing within task-relatedensembles and improved dexterity. Using a neural network model, we found that simulatedACS drove ensemble co-firing and enhanced propagation of neural activity through partsof the network with impaired connectivity, suggesting a mechanism to link increasedco-firing to enhanced dexterity. Together, our results demonstrate that ACS restoresneural processing in impaired networks and improves dexterity following stroke. Morebroadly, these results demonstrate approaches to optimize stimulation to target neuraldynamics.

DOI: 10.1016/j.cell.2021.01.023

Source: https://www.cell.com/cell/fulltext/S0092-8674(21)00066-0

期刊信息
Cell:《细胞》,创刊于1974年。隶属于细胞出版社,最新IF:36.216
官方网址:https://www.cell.com/