湖南大学谭蔚泓团队开发出基于DNA框架的人工DNA编码器的解码复杂自由基级联的策略。 相关研究成果于2021年2月8日发表于国际顶尖学术期刊《德国应用化学》。

基于DNA的分子通讯（DMC）对于调节生物网络以维持稳定的组织功能至关重要。然而，基因组编码的DMC所涉及的复杂、耗时的信息传递过程以及有限、易受攻击的解码活动通常在响应外界刺激时，导致通信损伤或失败。

该文中，研究人员提出了一个概念上创新的以DNA框架为基础的人工DNA编码器介导的DMC策略。通过自由基级联作为概念验证研究，人工DNA编码器显示出主动传感和实时驱动、原位和广泛的自由基解码功效，以及对环境噪声的强大抵抗力。它还可以阻断自由基和炎症网络之间不需要的中短程通讯，从而产生协同的减肥效果。

基于人工DNA编码器的DMC可以推广到其他通信系统的应用中。

附：英文原文

Title: Decoding the Complex Free Radical Cascade by a DNA Framework‐Based Artificial DNA Encoder

Author: Lili Zhang, Linlin Wang, Xi Yuan, Minjuan Zhong, Hong Chen, Dailiang Zhang, Xiaoyan Han, Sitao Xie, Lei He, Yazhou Li, Fengming Chen, Yanlan Liu, Weihong Tan

Issue&Volume: 2021-02-08

Abstract: DNA‐based molecular communications (DMC) are critical for regulating biological networks to maintain stable organismic functions. However, the complicated, time‐consuming information transmission process involved in genome‐coded DMC and the limited, vulnerable decoding activity generally lead to communication impairment or failure, in response to external stimuli. Herein, we present a conceptually innovative DMC strategy mediated by the DNA framework‐based artificial DNA encoder. With the free‐radical cascade as a proof‐of‐concept study, the artificial DNA encoder shows active sensing and real‐time actuation, in situ and broad free radical‐decoding efficacy, as well as robust resistance to environmental noises. It can also block undesirable short to medium‐range communications between free radicals and inflammatory networks, leading to a synergistic antiobesity effect. The artificial DNA encoder‐based DMC may be generalized to other communication systems for a variety of applications.

DOI: 10.1002/anie.202014088

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202014088