上海交通大学谭蔚泓及中科院赵宇亮、Liang Yan研究小组等报道等离子体AuPt@CuS异质结构用于具有增强协同效应的放射光热治疗。2021年9月28日出版的《美国化学会杂志》发表了这项成果。

在这项工作中，该研究团队报告了一种新型的等离子体异质结构，通过将AuPt纳米粒子(NPs)装饰到CuS纳米片(AuPt@CuS NSs)表面形成一种高效的纳米异质结构，用于双模态光声/计算机断层成像和增强协同放射光热治疗。

这些异质结构可以提供更高的光热转换效率，通过局部电磁增强以及以消耗谷胱甘肽形式的更大辐射剂量沉积和活性氧物种的产生。结果提高了组织穿透深度，缓解了肿瘤微环境缺氧。光热消融与放疗协同增强疗效，可消除肿瘤而不复发。

研究人员相信这些多功能异质结构将在未来的肿瘤治疗中发挥重要作用，在潜在的双通道系统引导成像下，放射治疗和光热消融的协同效应将得到增强。

据介绍，融合多功能纳米结构的放射治疗和光热消融术是杀灭癌细胞的新途径。

附：英文原文

Title: Plasmonic AuPt@CuS Heterostructure with Enhanced Synergistic Efficacy for Radiophotothermal Therapy

Author: Ren Cai, Huandong Xiang, Dan Yang, Keng-Te Lin, Yuanzheng Wu, Ruyi Zhou, Zhanjun Gu, Liang Yan, Yuliang Zhao, Weihong Tan

Issue&Volume: September 28, 2021

Abstract: Integrating multifunctional nanostructures capable of radiotherapy and photothermal ablation is an emerging alternative in killing cancer cells. In this work, we report a novel plasmonic heterostructure formed by decorating AuPt nanoparticles (NPs) onto the surfaces of CuS nanosheets (AuPt@CuS NSs) as a highly effective nanotheranostic toward dual-modal photoacoustic/computed tomography imaging and enhanced synergistic radiophotothermal therapy. These heterostructures can confer higher photothermal conversion efficiency via the local electromagnetic enhancement as well as a greater radiation dose deposition in the form of glutathione depletion and reactive oxygen species generation. As a result, the depth of tissue penetration is improved, and hypoxia of the tumor microenvironment is alleviated. With synergistic enhancement in the efficacy of photothermal ablation and radiotherapy, the tumor can be eliminated without later recurrence. It is believed that these multifunctional heterostructures will play a vital role in future oncotherapy with the enhanced synergistic effects of radiotherapy and photothermal ablation under the guided imaging of a potential dual-modality system.

DOI: 10.1021/jacs.1c06652

Source: https://pubs.acs.org/doi/10.1021/jacs.1c06652