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用于病媒控制和传粉者保护的吡虫啉晶型
作者:小柯机器人 发布时间:2021/10/17 15:57:07

美国纽约大学Bart Kahr开发了用于病媒控制和传粉者保护的吡虫啉晶型。相关研究成果发表在2021年10月12日出版的《美国化学会杂志》。

吡虫啉,世界领先的杀虫剂,最近被批准用于控制传染病媒介;然而,在农业环境中,它与传粉者的可怕下降有关。因此提出了大幅减少吡虫啉对环境影响的策略。当用作接触杀虫剂时,吡虫啉的效力取决于其晶体表面与昆虫跗骨之间的物理接触。

该文中,研究人员报告了七种新的吡虫啉晶体多晶型,增加到两种已知形式中。预计昆虫对吡虫啉分子的吸收将取决于晶体多晶型表面的各自自由能,亚稳晶体形式的昆虫击倒时间测量比商业形式对伊蚊、按蚊和库蚊以及果蝇的作用快9倍。以上结果表明,用三种新的多晶型(形态IV、VI、IX)中的任何一种替代商用吡虫啉晶体(也称为形态I)进行空间喷洒,可以抑制病媒传播疾病,同时减少环境暴露和对非目标生物体的伤害。

附:英文原文

Title: Imidacloprid Crystal Polymorphs for Disease Vector Control and Pollinator Protection

Author: Xiaolong Zhu, Chunhua T. Hu, Bryan Erriah, Leslie Vogt-Maranto, Jingxiang Yang, Yongfan Yang, Mengdi Qiu, Noalle Fellah, Mark E. Tuckerman, Michael D. Ward, Bart Kahr

Issue&Volume: October 12, 2021

Abstract: Imidacloprid, the world’s leading insecticide, has been approved recently for controlling infectious disease vectors; yet, in agricultural settings, it has been implicated in the frightening decline of pollinators. This argues for strategies that sharply reduce the environmental impact of imidacloprid. When used as a contact insecticide, the effectiveness of imidacloprid relies on physical contact between its crystal surfaces and insect tarsi. Herein, seven new imidacloprid crystal polymorphs are reported, adding to two known forms. Anticipating that insect uptake of imidacloprid molecules would depend on the respective free energies of crystal polymorph surfaces, measurements of insect knockdown times for the metastable crystal forms were as much as nine times faster acting than the commercial form against Aedes, Anopheles, and Culex mosquitoes as well as Drosophila (fruit flies). These results suggest that replacement of commercially available imidacloprid crystals (a.k.a. Form I) in space-spraying with any one of three new polymorphs, Forms IV, VI, IX, would suppress vector-borne disease transmission while reducing environmental exposure and harm to nontarget organisms.

DOI: 10.1021/jacs.1c07610

Source: https://pubs.acs.org/doi/10.1021/jacs.1c07610

 

期刊信息

JACS:《美国化学会志》,创刊于1879年。隶属于美国化学会,最新IF:14.612
官方网址:https://pubs.acs.org/journal/jacsat
投稿链接:https://acsparagonplus.acs.org/psweb/loginForm?code=1000