美国拉霍亚免疫学研究所Shane Crotty等研究人员合作评估感染后长达8个月的SARS-CoV-2免疫记忆。该研究于2021年1月6日在线发表于国际一流学术期刊《科学》。

研究人员分析了188名COVID-19病例的254个样本中多个针对SARS-CoV-2的循环免疫记忆，其中包括感染后6个月以上的43个样本。突刺蛋白的IgG在6个多月内相对稳定。症状发作后6个月，突刺特异性记忆B细胞比1个月时更为丰富。SARS-CoV-2特异性CD4⁺T细胞和CD8⁺T细胞下降，半衰期为3-5个月。

通过以整合方式研究针对SARS-CoV-2的抗体、记忆B细胞、CD4⁺T细胞和CD8⁺T细胞记忆，研究人员观察到SARS-CoV-2免疫记忆的每个成分均表现出不同的动力学。

据悉，了解SARS-CoV-2的免疫记忆对于改善诊断和疫苗以及评估COVID-19大流行的未来可能进程至关重要。

附：英文原文

Title: Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Author: Jennifer M. Dan, Jose Mateus, Yu Kato, Kathryn M. Hastie, Esther Dawen Yu, Caterina E. Faliti, Alba Grifoni, Sydney I. Ramirez, Sonya Haupt, April Frazier, Catherine Nakao, Vamseedhar Rayaprolu, Stephen A. Rawlings, Bjoern Peters, Florian Krammer, Viviana Simon, Erica Ollmann Saphire, Davey M. Smith, Daniela Weiskopf, Alessandro Sette, Shane Crotty

Issue&Volume: 2021/01/06

Abstract: Understanding immune memory to SARS-CoV-2 is critical for improving diagnostics and vaccines, and for assessing the likely future course of the COVID-19 pandemic. We analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at ≥ 6 months post-infection. IgG to the Spike protein was relatively stable over 6+ months. Spike-specific memory B cells were more abundant at 6 months than at 1 month post symptom onset. SARS-CoV-2-specific CD4+ T cells and CD8+ T cells declined with a half-life of 3-5 months. By studying antibody, memory B cell, CD4+ T cell, and CD8+ T cell memory to SARS-CoV-2 in an integrated manner, we observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics.

DOI: 10.1126/science.abf4063

Source: https://science.sciencemag.org/content/early/2021/01/05/science.abf4063