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高频神经调节能够改善强迫行为
作者:小柯机器人 发布时间:2021/1/20 17:03:45

美国波士顿大学Robert M. G. Reinhart团队发现,高频神经调节能够改善强迫行为。该项研究成果于2021年1月18日在线发表在《自然—医学》杂志上。

研究人员通过交流电靶向了眶额皮质,将其个性化为奖励网络的固有β-伽马频率,并通过增加探索力来显示快速、可逆、特定频率的奖励,但不受惩罚导向的选择行为和学习的调制。接下来,研究人员证明了在5个工作日内长期应用该程序可以在3个月内有效减弱非临床人群的强迫症行为,而且对症状更严重患者有最大好处。

最后,研究人员揭示了奖励学习的调节和强迫症症状减轻的基础。这些结果有助于奖励、学习和强迫行为的神经生理学理论,并表明节律在β-γ范围内的统一作用,这也为针对相关疾病的个性化疗法开发奠定了基础。

据了解,全世界将近十亿人患有强迫症行为,但是人们对这些行为的机制理解还不完整,也还没有有效的治疗方法。新兴的观点将强迫行为作为不良适应习惯学习的特征,这可能与奖励过程中眶额-纹状体回路的β-γ神经生理异常有关。

附:英文原文

Title: High-frequency neuromodulation improves obsessive–compulsive behavior

Author: Shrey Grover, John A. Nguyen, Vighnesh Viswanathan, Robert M. G. Reinhart

Issue&Volume: 2021-01-18

Abstract: Nearly one billion people worldwide suffer from obsessive–compulsive behaviors1,2, yet our mechanistic understanding of these behaviors is incomplete, and effective therapeutics are unavailable. An emerging perspective characterizes obsessive–compulsive behaviors as maladaptive habit learning3,4, which may be associated with abnormal beta–gamma neurophysiology of the orbitofrontal–striatal circuitry during reward processing5,6. We target the orbitofrontal cortex with alternating current, personalized to the intrinsic beta–gamma frequency of the reward network, and show rapid, reversible, frequency-specific modulation of reward- but not punishment-guided choice behavior and learning, driven by increased exploration in the setting of an actor-critic architecture. Next, we demonstrate that chronic application of the procedure over 5days robustly attenuates obsessive–compulsive behavior in a non-clinical population for 3months, with the largest benefits for individuals with more severe symptoms. Finally, we show that convergent mechanisms underlie modulation of reward learning and reduction of obsessive–compulsive symptoms. The results contribute to neurophysiological theories of reward, learning and obsessive–compulsive behavior, suggest a unifying functional role of rhythms in the beta–gamma range, and set the groundwork for the development of personalized circuit-based therapeutics for related disorders.

DOI: 10.1038/s41591-020-01173-w

Source: https://www.nature.com/articles/s41591-020-01173-w

期刊信息

Nature Medicine:《自然—医学》,创刊于1995年。隶属于施普林格·自然出版集团,最新IF:30.641
官方网址:https://www.nature.com/nm/
投稿链接:https://mts-nmed.nature.com/cgi-bin/main.plex