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全基因组关联研究确定了ABO组织血型抗原对肠道微生物组的影响
作者:小柯机器人 发布时间:2021/1/19 14:51:45

德国基尔大学Andre Franke及其团队的最新研究通过对8,956名德国人进行全基因组关联研究,确定了ABO组织血型抗原对肠道微生物组的影响。相关论文于2021年1月18发表在《自然-遗传学》杂志上。

通过对8,956名德国人进行全基因组关联分析,研究人员确定了38个遗传位点与单个细菌和整体微生物组组成有关。研究进一步分析证实了ABO组织血型抗原和FUT2分泌状态与拟杆菌和费氏杆菌属间的关联。孟德尔随机分析表明,肠道微生物具有致病性和保护性作用,对炎症性肠病具有进化枝特异性作用。将宿主遗传学及其相关微生物群落作为“新生物”的整体研究方法拓宽了人们对疾病病因的理解,并突出了微生物群在疾病治疗和控制过程中的潜力。

研究人员表示,肠道微生物组是多种炎症、神经系统疾病和肿瘤的重要调节因子。最近的全基因组关联研究产生了差异、不足和难以重复的结果,因此宿主遗传学对微生物组装配和结构的作用仍具有不确定性。然而,孪生子研究清楚地表明宿主遗传学是微生物组组成的驱动力。

附:英文原文

Title: Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome

Author: Malte Christoph Rhlemann, Britt Marie Hermes, Corinna Bang, Shauni Doms, Lucas Moitinho-Silva, Louise Bruun Thingholm, Fabian Frost, Frauke Degenhardt, Michael Wittig, Jan Kssens, Frank Ulrich Weiss, Annette Peters, Klaus Neuhaus, Uwe Vlker, Henry Vlzke, Georg Homuth, Stefan Weiss, Harald Grallert, Matthias Laudes, Wolfgang Lieb, Dirk Haller, Markus M. Lerch, John F. Baines, Andre Franke

Issue&Volume: 2021-01-18

Abstract: The intestinal microbiome is implicated as an important modulating factor in multiple inflammatory1,2, neurologic3 and neoplastic diseases4. Recent genome-wide association studies yielded inconsistent, underpowered and rarely replicated results such that the role of human host genetics as a contributing factor to microbiome assembly and structure remains uncertain5,6,7,8,9,10,11. Nevertheless, twin studies clearly suggest host genetics as a driver of microbiome composition11. In a genome-wide association analysis of 8,956 German individuals, we identified 38 genetic loci to be associated with single bacteria and overall microbiome composition. Further analyses confirm the identified associations of ABO histo-blood groups and FUT2 secretor status with Bacteroides and Faecalibacterium spp. Mendelian randomization analysis suggests causative and protective effects of gut microbes, with clade-specific effects on inflammatory bowel disease. This holistic investigative approach of the host, its genetics and its associated microbial communities as a ‘metaorganism’ broaden our understanding of disease etiology, and emphasize the potential for implementing microbiota in disease treatment and management.

DOI: 10.1038/s41588-020-00747-1

Source: https://www.nature.com/articles/s41588-020-00747-1

 

期刊信息

Nature Genetics:《自然—遗传学》,创刊于1992年。隶属于施普林格·自然出版集团,最新IF:25.455
官方网址:https://www.nature.com/ng/
投稿链接:https://mts-ng.nature.com/cgi-bin/main.plex