德国科隆大学Sara A. Wickström、Sabine A. Eming等研究人员合作发现,谷氨酰胺代谢调控毛囊干细胞的命运可逆性和长期维持。2020年9月8日,《细胞—代谢》杂志在线发表了这一研究成果。
Title: Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle
Author: Christine S. Kim, Xiaolei Ding, Kira Allmeroth, Leah C. Biggs, Olivia I. Kolenc, Nina L’Hoest, Carlos Andrés Chacón-Martínez, Christian Edlich-Muth, Patrick Giavalisco, Kyle P. Quinn, Martin S. Denzel, Sabine A. Eming, Sara A. Wickstrm
Issue&Volume: 2020-09-08
Abstract: Stem cells reside in specialized niches that are critical for their function. Uponactivation, hair follicle stem cells (HFSCs) exit their niche to generate the outerroot sheath (ORS), but a subset of ORS progeny returns to the niche to resume an SCstate. Mechanisms of this fate reversibility are unclear. We show that the abilityof ORS cells to return to the SC state requires suppression of a metabolic switchfrom glycolysis to oxidative phosphorylation and glutamine metabolism that occursduring early HFSC lineage progression. HFSC fate reversibility and glutamine metabolismare regulated by the mammalian target of rapamycin complex 2 (mTORC2)-Akt signalingaxis within the niche. Deletion of mTORC2 results in a failure to re-establish theHFSC niche, defective hair follicle regeneration, and compromised long-term maintenanceof HFSCs. These findings highlight the importance of spatiotemporal control of SCmetabolic states in organ homeostasis.
DOI: 10.1016/j.cmet.2020.08.011
Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30424-1
Cell Metabolism:《细胞—代谢》,创刊于2005年。隶属于细胞出版社,最新IF:22.415
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