当前位置:科学网首页 > 小柯机器人 >详情
谷氨酸代谢能调控毛囊干细胞命运
作者:小柯机器人 发布时间:2020/9/9 15:35:19

德国科隆大学Sara A. Wickström、Sabine A. Eming等研究人员合作发现,谷氨酰胺代谢调控毛囊干细胞的命运可逆性和长期维持。2020年9月8日,《细胞—代谢》杂志在线发表了这一研究成果。

研究人员表示,干细胞位于对其功能至关重要的特殊微环境中。当激活后,毛囊干细胞(HFSC)退出其微环境,进而产生外根鞘(ORS),但是ORS子代中一类细胞又会返回到这个微环境中,并恢复SC状态。这种细胞命运可逆性的机制尚不清楚。
 
研究人员发现,ORS细胞返回SC状态需要抑制从糖酵解到氧化磷酸化和谷氨酰胺代谢的新陈代谢转换,这一转换发生在早期HFSC谱系进展中。HFSC的命运可逆性和谷氨酰胺代谢受微环境内mTORC2-Akt信号轴的调控。敲除mTORC2能够导致HFSC微环境重建的失败、毛囊再生不良以及HFSC长期维护的损害。
 
这些发现强调了器官稳态中SC代谢状态时空性调控的重要性。
 
附:英文原文

Title: Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle

Author: Christine S. Kim, Xiaolei Ding, Kira Allmeroth, Leah C. Biggs, Olivia I. Kolenc, Nina L’Hoest, Carlos Andrés Chacón-Martínez, Christian Edlich-Muth, Patrick Giavalisco, Kyle P. Quinn, Martin S. Denzel, Sabine A. Eming, Sara A. Wickstrm

Issue&Volume: 2020-09-08

Abstract: Stem cells reside in specialized niches that are critical for their function. Uponactivation, hair follicle stem cells (HFSCs) exit their niche to generate the outerroot sheath (ORS), but a subset of ORS progeny returns to the niche to resume an SCstate. Mechanisms of this fate reversibility are unclear. We show that the abilityof ORS cells to return to the SC state requires suppression of a metabolic switchfrom glycolysis to oxidative phosphorylation and glutamine metabolism that occursduring early HFSC lineage progression. HFSC fate reversibility and glutamine metabolismare regulated by the mammalian target of rapamycin complex 2 (mTORC2)-Akt signalingaxis within the niche. Deletion of mTORC2 results in a failure to re-establish theHFSC niche, defective hair follicle regeneration, and compromised long-term maintenanceof HFSCs. These findings highlight the importance of spatiotemporal control of SCmetabolic states in organ homeostasis.

DOI: 10.1016/j.cmet.2020.08.011

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30424-1

期刊信息

Cell Metabolism:《细胞—代谢》,创刊于2005年。隶属于细胞出版社,最新IF:22.415
官方网址:https://www.cell.com/cell-metabolism/home
投稿链接:https://www.editorialmanager.com/cell-metabolism/default.aspx