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解剖上分离的基底神经节通路允许平行行为调节
作者:小柯机器人 发布时间:2020/9/30 15:27:01

美国哈佛医学院Bernardo L. Sabatini研究组近日的一项新成果表明,解剖上分离的基底神经节通路允许平行行为调节。2020年9月28日,《自然—神经科学》杂志在线发表了这项成果。

通过使用局部顺式突触顺行性示踪,研究人员发现在所有基底神经节(BG)输出核中都保留了纹状体与运动相关的位置组织。地形也保持在BG的下游,并在多个平行的闭合回路中提供纹状体输入。此外,两个不同纹状体区域的局部激活诱导舔食或转向,这与其在BG外投射的各自解剖学靶标一致。这些结果证实了BG功能的并行模型,并表明不同行为相关信息的集成和竞争主要发生在BG之外。
 
据介绍,在BG中,解剖和位置上分离组织的前馈回路被认为可以并行调节多种行为。尽管已经描述了位置排列的BG电路,但是这些关系在BG输出核和下游目标中维持的程度尚不清楚。
 
附:英文原文

Title: Anatomically segregated basal ganglia pathways allow parallel behavioral modulation

Author: Jaeeon Lee, Wengang Wang, Bernardo L. Sabatini

Issue&Volume: 2020-09-28

Abstract: In the basal ganglia (BG), anatomically segregated and topographically organized feedforward circuits are thought to modulate multiple behaviors in parallel. Although topographically arranged BG circuits have been described, the extent to which these relationships are maintained across the BG output nuclei and in downstream targets is unclear. Here, using focal trans-synaptic anterograde tracing, we show that the motor-action-related topographical organization of the striatum is preserved in all BG output nuclei. The topography is also maintained downstream of the BG and in multiple parallel closed loops that provide striatal input. Furthermore, focal activation of two distinct striatal regions induces either licking or turning, consistent with their respective anatomical targets of projection outside of the BG. Our results confirm the parallel model of BG function and suggest that the integration and competition of information relating to different behavior occur largely outside of the BG. This study demonstrates that basal ganglia functional topography is maintained across and downstream of its output nuclei, and in closed loops. Focal stimulation of distinct striatal subregions induces distinct action, supporting a model of parallel behavioral control.

DOI: 10.1038/s41593-020-00712-5

Source: https://www.nature.com/articles/s41593-020-00712-5

期刊信息

Nature Neuroscience:《自然—神经科学》,创刊于1998年。隶属于施普林格·自然出版集团,最新if:21.126
官方网址:https://www.nature.com/neuro/
投稿链接:https://mts-nn.nature.com/cgi-bin/main.plex