美国哈佛医学院Bernardo L. Sabatini研究组近日的一项新成果表明，解剖上分离的基底神经节通路允许平行行为调节。2020年9月28日，《自然—神经科学》杂志在线发表了这项成果。

Title: Anatomically segregated basal ganglia pathways allow parallel behavioral modulation

Author: Jaeeon Lee, Wengang Wang, Bernardo L. Sabatini

Issue&Volume: 2020-09-28

Abstract: In the basal ganglia (BG), anatomically segregated and topographically organized feedforward circuits are thought to modulate multiple behaviors in parallel. Although topographically arranged BG circuits have been described, the extent to which these relationships are maintained across the BG output nuclei and in downstream targets is unclear. Here, using focal trans-synaptic anterograde tracing, we show that the motor-action-related topographical organization of the striatum is preserved in all BG output nuclei. The topography is also maintained downstream of the BG and in multiple parallel closed loops that provide striatal input. Furthermore, focal activation of two distinct striatal regions induces either licking or turning, consistent with their respective anatomical targets of projection outside of the BG. Our results confirm the parallel model of BG function and suggest that the integration and competition of information relating to different behavior occur largely outside of the BG. This study demonstrates that basal ganglia functional topography is maintained across and downstream of its output nuclei, and in closed loops. Focal stimulation of distinct striatal subregions induces distinct action, supporting a model of parallel behavioral control.

DOI: 10.1038/s41593-020-00712-5

Source: https://www.nature.com/articles/s41593-020-00712-5