研究揭示致命性COVID-19肺炎患者中的自身抗体特征
作者：小柯机器人 发布时间：2020/9/26 10:04:48
法国巴黎大学Jean-Laurent Casanova等研究人员合作揭示致命性COVID-19肺炎患者中的自身抗体特征。2020年9月24日，《科学》杂志在线发表了这项研究成果。
研究人员发现，在987例危及生命的COVID-19肺炎患者中，至少101例在危重病发作时具有针对IFN-ω（13例患者）、13种IFN-α（36例）或两者兼而有之（52例）的中和性IgG自身抗体；少数患者还具有针对其他三种I型IFN的自身抗体。自身抗体可中和相应的I型干扰素在体外阻断SARS-CoV-2感染的能力。
在663例无症状或轻度SARS-CoV-2感染者中未发现这些自身抗体，1227例健康个体中只有4例存在。具有自身抗体的患者年龄为25～87岁，男性为95例。在至少2.6%的女性和12.5%的男性中，先天性I型干扰素免疫错误的B细胞自身免疫表型是致命性COVID-19肺炎的基础。
据介绍，SARS-CoV-2感染过程中个体间的临床变异性是巨大的。
附：英文原文
Title:Auto-antibodies against type I IFNs in patients with life-threatening COVID-19
Author:Paul Bastard1,2,3,*,†, View ORCID ProfileLindsey B. Rosen4,†, View ORCID ProfileQian Zhang3,‡, View ORCID ProfileEleftherios Michailidis5,‡,
Issue&Volume:24 Sep 2020:
Abstract: Interindividual clinical variability in the course of SARS-CoV-2 infection is immense. We report that at least 101 of 987 patients with life-threatening COVID-19 pneumonia had neutralizing IgG auto-Abs against IFN-ω (13 patients), the 13 types of IFN-α (36), or both (52), at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1,227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 were men. A B cell auto-immune phenocopy of inborn errors of type I IFN immunity underlies life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.
DOI:DOI: 10.1126/science.abd4585
Source: https://science.sciencemag.org/content/early/2020/09/23/science.abd4585
期刊信息
Science：《科学》，创刊于1880年。隶属于美国科学促进会，最新IF：41.037