中国科学院脑科学与智能卓越创新中心陈跃军等研究人员发现，人类干细胞（hESC）衍生的神经元可修复回路并恢复神经功能。该研究于2020年9月22日在线发表于国际一流学术期刊《细胞—干细胞》。

Title: Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function

Author: Man Xiong, Yezheng Tao, Qinqin Gao, Ban Feng, Wei Yan, Yingying Zhou, Thomas A. Kotsonis, Tingli Yuan, Zhiwen You, Ziyan Wu, Jiajie Xi, Alexander Haberman, Julia Graham, Jasper Block, Wenhao Zhou, Yuejun Chen, Su-Chun Zhang

Issue&Volume: 2020-09-22

Abstract: Although cell transplantation can rescue motor defects in Parkinson’s disease (PD)models, whether and how grafts functionally repair damaged neural circuitry in theadult brain is not known. We transplanted hESC-derived midbrain dopamine (mDA) orcortical glutamate neurons into the substantia nigra or striatum of a mouse PD model and found extensive graft integration with host circuitry.Axonal pathfinding toward the dorsal striatum was determined by the identity of thegrafted neurons, and anatomical presynaptic inputs were largely dependent on graftlocation, whereas inhibitory versus excitatory input was dictated by the identityof grafted neurons. hESC-derived mDA neurons display A9 characteristics and restorefunctionality of the reconstructed nigrostriatal circuit to mediate improvements inmotor function. These results indicate similarity in cell-type-specific pre- and post-synapticintegration between transplant-reconstructed circuit and endogenous neural networks,highlighting the capacity of hPSC-derived neuron subtypes for specific circuit repairand functional restoration in the adult brain.

DOI: 10.1016/j.stem.2020.08.014

Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(20)30410-0