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卡介苗接种可预防老年人感染
作者：小柯机器人 发布时间：2020/9/2 16:20:31

希腊ATTIKON大学Evangelos J. Giamarellos-Bourboulis等研究人员发现，卡介苗接种可预防老年人感染。2020年8月31日，《细胞》在线发表了这一成果。

研究人员表示，儿童接种卡介苗（BCG）可预防异源感染，并独立于结核病预防而提高生存率。ACTIVATE III期试验评估了BCG是否对老年人有类似作用。在这项双盲、随机试验中，老年患者（n=198）在出院时接种了BCG或安慰剂疫苗，并随访了12个月以进行新的感染。
 
在中期分析中，BCG疫苗接种显著增加了首次感染的时间（中位数为16周，而安慰剂后为11周）。安慰剂疫苗接种后新感染的发生率为42.3％（95％CIs：31.9-53.4％），BCG疫苗接种后为25.0％（95％CIs：16.4-36.16％）；大多数防护措施是针对可能由病毒引起的呼吸道感染（危险比0.21，p值：0.013）。没有发现不良反应发生频率的差异。
 
数据表明，BCG接种是安全的，可以保护老年人免受感染。目前需要更大的研究来进一步评估对呼吸道感染（包括COVID-19）的防护作用。
 
附：英文原文

Title: ACTIVATE: RANDOMIZED CLINICAL TRIAL OF BCG VACCINATION AGAINST INFECTION IN THE ELDERLY

Author: Evangelos J. Giamarellos-Bourboulis, Maria Tsilika, Simone Moorlag, Nikolaos Antonakos, Antigone Kotsaki, Jorge Domínguez-Andrés, Evdoxia Kyriazopoulou, Theologia Gkavogianni, Maria-Evangelia Adami, Georgia Damoraki, Panagiotis Koufargyris, Athanassios Karageorgos, Amalia Bolanou, Hans Koenen, Reinout van Crevel, Dionyssia-Irene Droggiti, George Renieris, Antonios Papadopoulos, Mihai G. Netea

Issue&Volume: 2020-08-31

Abstract: BCG vaccination in children protects against heterologous infections and improvessurvival independently of tuberculosis prevention. The phase III ACTIVATE trial assessedwhether BCG has similar effects in the elderly. In this double-blind, randomized trial,elderly patients (n=198) received BCG or placebo vaccine at hospital discharge, andwere followed for 12 months for new infections. At interim analysis, BCG vaccinationsignificantly increased the time to first infection (median 16 weeks compared to 11weeks after placebo). The incidence of new infections was 42.3% (95% CIs 31.9-53.4%)after placebo vaccination and 25.0% (95% CIs 16.4-36.16%) after BCG vaccination; mostof the protection was against respiratory tract infections of probable viral origin(hazard ratio 0.21, p: 0.013). No difference in the frequency of adverse effects wasfound. Data show that BCG vaccination is safe and can protect the elderly againstinfections. Larger studies are needed to assess protection against respiratory infections,including COVID-19.

DOI: 10.1016/j.cell.2020.08.051

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)31139-9

期刊信息
Cell：《细胞》，创刊于1974年。隶属于细胞出版社，最新IF：36.216
官方网址：https://www.cell.com/