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饮食可通过翻译后修饰影响小鼠肠道微生物蛋白质组
作者:小柯机器人 发布时间:2020/9/18 15:26:37

美国哈佛大学Wendy S. Garrett课题组发现,饮食可通过翻译后修饰影响小鼠肠道微生物蛋白质组,从而调节肾功能。相关论文于2020年9月18日发表在《科学》杂志上。

在慢性肾脏病(CKD)小鼠模型中,研究人员发现高硫氨基酸饮食会导微生物色氨酸酶活性的致翻译后修饰。这降低了小鼠产生尿毒症毒素的活性并改善了CKD的进展。因此,饮食可以通过翻译后修饰来调节微生物群的功能,从而促进健康的宿主生理,而无需改变微生物群落组成。
 
据了解,CKD与肠道菌群之间的关联已被发现,但有关机制仍未解析。在人类中,饮食蛋白会增加肠道细菌产生硫化氢(H2S)、吲哚和吲哚酚硫酸盐的能力。后者是尿毒症毒素,H2S具有多种生理功能,其中某些功能是由翻译后修饰介导的。
 
附:英文原文

Title: Diet posttranslationally modifies the mouse gut microbial proteome to modulate renal function

Author: Lior Lobel, Y. Grace Cao, Kathrin Fenn, Jonathan N. Glickman, Wendy S. Garrett

Issue&Volume: 2020/09/18

Abstract: Associations between chronic kidney disease (CKD) and the gut microbiota have been postulated, yet questions remain about the underlying mechanisms. In humans, dietary protein increases gut bacterial production of hydrogen sulfide (H2S), indole, and indoxyl sulfate. The latter are uremic toxins, and H2S has diverse physiological functions, some of which are mediated by posttranslational modification. In a mouse model of CKD, we found that a high sulfur amino acid–containing diet resulted in posttranslationally modified microbial tryptophanase activity. This reduced uremic toxin–producing activity and ameliorated progression to CKD in the mice. Thus, diet can tune microbiota function to support healthy host physiology through posttranslational modification without altering microbial community composition.

DOI: 10.1126/science.abb3763

Source: https://science.sciencemag.org/content/369/6510/1518

期刊信息
Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037