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保暖是通过肠道微生物来阻止骨质流失
作者:小柯机器人 发布时间:2020/9/12 15:19:48

瑞士日内瓦大学Mirko Trajkovski课题组发现,温暖通过肠道微生物来阻止骨质流失。这一研究成果于2020年9月10日在线发表在《细胞—代谢》上。

研究人员表明,温暖(34°C)通过增加小梁骨的体积、连接密度和厚度来防止卵巢切除术引起的骨质流失,从而提高成年雌性以及年轻雄性小鼠的生物力学骨强度。温暖适应型微生物群的表型复制了温暖引起的骨骼效应。温暖和温暖型微生物群移植均可逆转卵巢切除术引起的胫骨转录组学变化,并增加骨膜骨的形成。

组合宏基因组学/代谢组学分析表明,温度增强细菌多胺的生物合成,导致体内总多胺水平更高。补充精胺和亚精胺可增强骨骼强度,而在体内抑制多胺生物合成限制了对骨骼有益的保暖作用。这些数据表明,温热暴露可作为骨质疏松症的潜在治疗选择,同时为其在骨病中的益处提供机制。

据介绍,骨质疏松症是最普遍的代谢性骨疾病,其特征是骨量低和微结构恶化。

附:英文原文

Title: Warmth Prevents Bone Loss Through the Gut Microbiota

Author: Claire Chevalier, Silas Kieser, Melis olakolu, Noushin Hadadi, Julia Brun, Dorothée Rigo, Nicolas Suárez-Zamorano, Martina Spiljar, Salvatore Fabbiano, Bjrn Busse, Julijana Ivanievi, Andrew Macpherson, Nicolas Bonnet, Mirko Trajkovski

Issue&Volume: 2020-09-10

Abstract: Osteoporosis is the most prevalent metabolic bone disease, characterized by low bonemass and microarchitectural deterioration. Here, we show that warmth exposure (34°C)protects against ovariectomy-induced bone loss by increasing trabecular bone volume,connectivity density, and thickness, leading to improved biomechanical bone strengthin adult female, as well as in young male mice. Transplantation of the warm-adaptedmicrobiota phenocopies the warmth-induced bone effects. Both warmth and warm microbiotatransplantation revert the ovariectomy-induced transcriptomics changes of the tibiaand increase periosteal bone formation. Combinatorial metagenomics/metabolomics analysisshows that warmth enhances bacterial polyamine biosynthesis, resulting in higher totalpolyamine levels in vivo. Spermine and spermidine supplementation increases bone strength, while inhibitingpolyamine biosynthesis in vivo limits the beneficial warmth effects on the bone. Our data suggest warmth exposureas a potential treatment option for osteoporosis while providing a mechanistic frameworkfor its benefits in bone disease.

DOI: 10.1016/j.cmet.2020.08.012

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30425-3

期刊信息

Cell Metabolism:《细胞—代谢》,创刊于2005年。隶属于细胞出版社,最新IF:22.415
官方网址:https://www.cell.com/cell-metabolism/home
投稿链接:https://www.editorialmanager.com/cell-metabolism/default.aspx