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研究发现唤起老鼠“父亲担当”行为的神经激素回路
作者:小柯机器人 发布时间:2020/8/9 14:51:57

瑞典卡罗林斯卡学院Christian Broberger、Stefanos Stagkourakis等研究人员合作发现,下丘脑网络振荡控制父亲行为的神经激素回路。该项研究成果于2020年8月6日在线发表在《细胞》杂志上。

使用Sprague-Dawley大鼠和C57BL/6小鼠(父系谱两端的两个物种),研究人员发现,神经内分泌多巴胺神经元中不同的电振荡模式与低多巴胺释放、高循环泌乳素、视泌乳素受体依赖的内侧视前区甘丙肽神经元的激活以及父系小鼠的行为密切相关。在大鼠中,相同的参数表现出相反的特征。对这些节律的光遗传学操作在小鼠中大大改变了血清催乳素和父本行为,而将催乳素注射到非父本大鼠中则引发了父母照护的表现。这些发现表明,一种频率调节的大脑-内分泌-大脑回路可作为一种确定物种父母策略的控制系统。
 
据悉,父母行为普遍存在于整个动物界,对物种生存至关重要。但是,父亲对后代照料的相对贡献在不同的动物之间,甚至在相关物种之间,也明显不同。组织和控制父亲行为的机制仍然知之甚少。
 
附:英文原文

Title: A Neuro-hormonal Circuit for Paternal Behavior Controlled by a Hypothalamic Network Oscillation

Author: Stefanos Stagkourakis, Kristina O. Smiley, Paul Williams, Sarah Kakadellis, Katharina Ziegler, Joanne Bakker, Rosemary S.E. Brown, Tibor Harkany, David R. Grattan, Christian Broberger

Issue&Volume: 2020-08-06

Abstract: Parental behavior is pervasive throughout the animal kingdom and essential for species survival. However, the relative contribution of the father to offspring care differs markedly across animals, even between related species. The mechanisms that organize and control paternal behavior remain poorly understood. Using Sprague-Dawley rats and C57BL/6 mice, two species at opposite ends of the paternal spectrum, we identified that distinct electrical oscillation patterns in neuroendocrine dopamine neurons link to a chain of low dopamine release, high circulating prolactin, prolactin receptor-dependent activation of medial preoptic area galanin neurons, and paternal care behavior in male mice. In rats, the same parameters exhibit inverse profiles. Optogenetic manipulation of these rhythms in mice dramatically shifted serum prolactin and paternal behavior, whereas injecting prolactin into non-paternal rat sires triggered expression of parental care. These findings identify a frequency-tuned brain-endocrine-brain circuit that can act as a gain control system determining a species’ parental strategy.

DOI: 10.1016/j.cell.2020.07.007

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)30872-2

期刊信息
Cell:《细胞》,创刊于1974年。隶属于细胞出版社,最新IF:36.216
官方网址:https://www.cell.com/