英国伦敦大学学院Buzz Baum、兰卡斯特大学Nicholas P. Robinson等研究人员合作发现蛋白酶体控制古细菌中ESCRT-III介导的细胞分裂。这一研究成果发表在2020年8月7日出版的《科学》上。

Title: The proteasome controls ESCRT-III–mediated cell division in an archaeon

Author: Gabriel Tarrason Risa, Fredrik Hurtig, Sian Bray, Anne E. Hafner, Lena Harker-Kirschneck, Peter Faull, Colin Davis, Dimitra Papatziamou, Delyan R. Mutavchiev, Catherine Fan, Leticia Meneguello, Andre Arashiro Pulschen, Gautam Dey, Sian Culley, Mairi Kilkenny, Diorge P. Souza, Luca Pellegrini, Robertus A. M. de Bruin, Ricardo Henriques, Ambrosius P. Snijders, Anela ari, Ann-Christin Linds, Nicholas P. Robinson, Buzz Baum

Issue&Volume: 2020/08/07

Abstract: Sulfolobus acidocaldarius is the closest experimentally tractable archaeal relative of eukaryotes and, despite lacking obvious cyclin-dependent kinase and cyclin homologs, has an ordered eukaryote-like cell cycle with distinct phases of DNA replication and division. Here, in exploring the mechanism of cell division in S. acidocaldarius, we identify a role for the archaeal proteasome in regulating the transition from the end of one cell cycle to the beginning of the next. Further, we identify the archaeal ESCRT-III homolog, CdvB, as a key target of the proteasome and show that its degradation triggers division by allowing constriction of the CdvB1:CdvB2 ESCRT-III division ring. These findings offer a minimal mechanism for ESCRT-III–mediated membrane remodeling and point to a conserved role for the proteasome in eukaryotic and archaeal cell cycle control.

DOI: 10.1126/science.aaz2532

Source: https://science.sciencemag.org/content/369/6504/eaaz2532