以色列希伯来大学Inbal Goshen课题组发现,星形胶质细胞在学习过程中通过调节海马-皮质交流来促进远程记忆形成。2020年8月3日,《自然—神经科学》杂志在线发表了这项成果。
Title: Astrocytes contribute to remote memory formation by modulating hippocampal–cortical communication during learning
Author: Adi Kol, Adar Adamsky, Maya Groysman, Tirzah Kreisel, Michael London, Inbal Goshen
Issue&Volume: 2020-08-03
Abstract: Remote memories depend on coordinated activity in the hippocampus and frontal cortices, but the timeline of these interactions is debated. Astrocytes sense and modify neuronal activity, but their role in remote memory is scarcely explored. We expressed the Gi-coupled designer receptor hM4Di in CA1 astrocytes and discovered that astrocytic manipulation during learning specifically impaired remote, but not recent, memory recall and decreased activity in the anterior cingulate cortex (ACC) during retrieval. We revealed massive recruitment of ACC-projecting CA1 neurons during memory acquisition, which was accompanied by the activation of ACC neurons. Astrocytic Gi activation disrupted CA3 to CA1 communication in vivo and reduced the downstream response in the ACC. In behaving mice, it induced a projection-specific inhibition of CA1-to-ACC neurons during learning, which consequently prevented ACC recruitment. Finally, direct inhibition of CA1-to-ACC-projecting neurons spared recent and impaired remote memory. Our findings suggest that remote memory acquisition involves projection-specific functions of astrocytes in regulating CA1-to-ACC neuronal communication. Kol et al. show that the foundation of remote memory is formed during acquisition by the massive recruitment of ACC-projecting CA1 neurons. Remote memory acquisition involves projection-specific effects of astrocytes on CA1-to-ACC neuronal communication.
DOI: 10.1038/s41593-020-0679-6
Source: https://www.nature.com/articles/s41593-020-0679-6
Nature Neuroscience:《自然—神经科学》,创刊于1998年。隶属于施普林格·自然出版集团,最新if:21.126
官方网址:https://www.nature.com/neuro/
投稿链接:https://mts-nn.nature.com/cgi-bin/main.plex