美国哈佛大学Galit Alter、华盛顿大学Helen Chu等研究人员合作发现，独特的早期血清学特征可指征SARS-CoV-2的存活率。2020年7月30日，《免疫》杂志在线发表了这项成果。

Title: Distinct early serological signatures track with SARS-CoV-2 survival

Author: Caroline Atyeo, Stephanie Fischinger, Tomer Zohar, Matthew D. Slein, John Burke, Carolin Loos, Denise J. McCulloch, Kira L. Newman, Caitlin Wolf, Jingyou Yu, Kiel Shuey, Jared Feldman, Blake Marie Hauser, Tim Caradonna, Aaron Schmidt, Todd J. Suscovich, Caitlyn Linde, Yongfei Cai, Dan Barouch, Edward T. Ryan, Richelle C. Charles, Douglas Lauffenburger, Helen Chu, Galit Alter

Issue&Volume: 2020-07-30

Abstract: As SARS-CoV-2 infections and death counts continue to rise, it remains unclear why some individuals recover from infection whereas others rapidly progress and die. While the immunological mechanisms that underlie different clinical trajectories remain poorly defined, pathogen-specific antibodies often point to immunological mechanisms of protection. Here, we profiled SARS-CoV-2–specific humoral responses on a cohort of 22 hospitalized individuals. Despite inter-individual heterogeneity, distinct antibody signatures resolved individuals with different outcomes. While no differences in SARS-CoV-2-specific IgG levels were observed, spike–specific humoral responses were enriched among convalescent individuals, whereas functional antibody responses to the nucleocapsid were elevated in deceased individuals. Furthermore, this enriched immunodominant S-specific antibody profile in convalescents was confirmed in a larger validation cohort. These results demonstrate that early antigen-specific and qualitative features of SARS-CoV-2-specific antibodies, point to differences in disease trajectory, highlighting the potential importance of functional antigen-specific humoral immunity to guide patient care and vaccine development.

DOI: 10.1016/j.immuni.2020.07.020

Source: https://www.cell.com/immunity/fulltext/S1074-7613(20)30327-7