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异质微生物群降解木质纤维素产生短链脂肪酸
作者:小柯机器人 发布时间:2020/8/28 17:21:48

瑞士伯尔尼应用科技大学(BFH)Michael H. Studer小组近日取得一项新成果。他们发现异质微生物群降解木质纤维素产生短链脂肪酸。相关论文发表在2020年8月28日的《科学》杂志上。

研究人员设计了一种多样微生物联合培养策略,可将木质纤维素直接转化为短链脂肪酸,包括将木质纤维素碳水化合物转化为乳酸,乳酸是食物加工过程的核心中间体。空间小生境有助于原位纤维素分解酶的产生,这是通过好氧真菌传递给兼性厌氧乳酸菌和形成产物的厌氧菌实现的。

将酪酸梭状芽胞杆菌、产碱韦荣球菌或埃氏巨球形菌加入到乳酸平台,每吨山毛榉木可生产196公斤丁酸。乳酸平台展示了混合培养的优势,例如它们的模块化以及将复杂底物转化为有价值生化试剂的潜能。

据介绍,对于复杂生物转化过程,微生物群落可能是替代单一转基因微生物培养的潜在策略。

附:英文原文

Title: A heterogeneous microbial consortium producing short-chain fatty acids from lignocellulose

Author: Robert L. Shahab, Simone Brethauer, Matthew P. Davey, Alison G. Smith, Silvia Vignolini, Jeremy S. Luterbacher, Michael H. Studer

Issue&Volume: 2020/08/28

Abstract: Microbial consortia are a promising alternative to monocultures of genetically modified microorganisms for complex biotransformations. We developed a versatile consortium-based strategy for the direct conversion of lignocellulose to short-chain fatty acids, which included the funneling of the lignocellulosic carbohydrates to lactate as a central intermediate in engineered food chains. A spatial niche enabled in situ cellulolytic enzyme production by an aerobic fungus next to facultative anaerobic lactic acid bacteria and the product-forming anaerobes. Clostridium tyrobutyricum, Veillonella criceti, or Megasphaera elsdenii were integrated into the lactate platform to produce 196 kilograms of butyric acid per metric ton of beechwood. The lactate platform demonstrates the benefits of mixed cultures, such as their modularity and their ability to convert complex substrates into valuable biochemicals.

DOI: 10.1126/science.abb1214

Source: https://science.sciencemag.org/content/369/6507/eabb1214

期刊信息
Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037