中科院分子植物科学卓越创新中心Rosa Lozano-Duran课题组发现一条连接质膜和叶绿体的病原体防御途径。相关论文于2020年8月24日在线发表在《细胞》杂志上。

Title: A Defense Pathway Linking Plasma Membrane and Chloroplasts and Co-opted by Pathogens

Author: Laura Medina-Puche, Huang Tan, Vivek Dogra, Mengshi Wu, Tabata Rosas-Diaz, Liping Wang, Xue Ding, Dan Zhang, Xing Fu, Chanhong Kim, Rosa Lozano-Duran

Issue&Volume: 2020-08-24

Abstract: Chloroplasts are crucial players in the activation of defensive hormonal responsesduring plant-pathogen interactions. Here, we show that a plant virus-encoded proteinre-localizes from the plasma membrane to chloroplasts upon activation of plant defense,interfering with the chloroplast-dependent anti-viral salicylic acid (SA) biosynthesis.Strikingly, we have found that plant pathogens from different kingdoms seem to haveconvergently evolved to target chloroplasts and impair SA-dependent defenses followingan association with membranes, which relies on the co-existence of two subcellulartargeting signals, an N-myristoylation site and a chloroplast transit peptide. Thispattern is also present in plant proteins, at least one of which conversely activatesSA defenses from the chloroplast. Taken together, our results suggest that a pathwaylinking plasma membrane to chloroplasts and activating defense exists in plants andthat such pathway has been co-opted by plant pathogens during host-pathogen co-evolutionto promote virulence through suppression of SA responses.

DOI: 10.1016/j.cell.2020.07.020

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)30885-0