美国纽约州立大学布法罗分校Bogdan Beirowski小组的最新发现表明，施万细胞的糖酵解转变影响轴突损伤。这一研究成果于2020年8月17日在线发表在国际学术期刊《自然—神经科学》上。

Title: A glycolytic shift in Schwann cells supports injured axons

Author: Elisabetta Babetto, Keit Men Wong, Bogdan Beirowski

Issue&Volume: 2020-08-17

Abstract: Axon degeneration is a hallmark of many neurodegenerative disorders. The current assumption is that the decision of injured axons to degenerate is cell-autonomously regulated. Here we show that Schwann cells (SCs), the glia of the peripheral nervous system, protect injured axons by virtue of a dramatic glycolytic upregulation that arises in SCs as an inherent adaptation to axon injury. This glycolytic response, paired with enhanced axon–glia metabolic coupling, supports the survival of axons. The glycolytic shift in SCs is largely driven by the metabolic signaling hub, mammalian target of rapamycin complex 1, and the downstream transcription factors hypoxia-inducible factor 1-alpha and c-Myc, which together promote glycolytic gene expression. The manipulation of glial glycolytic activity through this pathway enabled us to accelerate or delay the degeneration of perturbed axons in acute and subacute rodent axon degeneration models. Thus, we demonstrate a non-cell-autonomous metabolic mechanism that controls the fate of injured axons.

DOI: 10.1038/s41593-020-0689-4

Source: https://www.nature.com/articles/s41593-020-0689-4