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严重COVID-19的特征是髓样细胞区室失调
作者:小柯机器人 发布时间:2020/8/7 13:45:09

德国伯恩大学Joachim L. Schultze等研究人员合作发现,严重COVID-19的特征是髓样细胞区室失调。该项研究成果于2020年8月5日在线发表在《细胞》杂志上。

在一项双中心、两个队列的研究中,研究人员将全血和外周血单核细胞的单细胞RNA测序和单细胞蛋白质组学相结合,以确定轻度和重度COVID-19的免疫细胞组成和活化变化(从109个个体中抽取242个样本)。在轻度COVID-19中,具有干扰素刺激基因标记的HLA-DRhiCD11chi炎性单核细胞升高。严重的COVID-19以中性粒细胞前体的出现为标志,可作为紧急骨髓细胞生成、功能异常的成熟中性粒细胞和HLA-DRlo单核细胞的证据。
 
这项研究提供了对SARS-CoV-2感染全身性免疫反应的详细见解,它揭示了与严重COVID-19相关骨髓细胞区室的变化。
 
据悉,2019冠状病毒病(COVID-19)是轻度至中度的呼吸道感染,但是,部分患者会发展为严重疾病和呼吸衰竭。轻度保护性免疫的机制以及严重COVID-19的发病机制与中性粒细胞计数增加和免疫反应失调有关,但目前尚不清楚。
 
附:英文原文

Title: Severe COVID-19 is marked by a dysregulated myeloid cell compartment

Author: Jonas Schulte-Schrepping, Nico Reusch, Daniela Paclik, Kevin Baler, Stephan Schlickeiser, Bowen Zhang, Benjamin Krmer, Tobias Krammer, Sophia Brumhard, Lorenzo Bonaguro, Elena De Domenico, Daniel Wendisch, Martin Grasshoff, Theodore S. Kapellos, Michael Beckstette, Tal Pecht, Adem Saglam, Oliver Dietrich, Henrik E. Mei, Axel R. Schulz, Claudia Conrad, Désirée Kunkel, Ehsan Vafadarnejad, Cheng-Jian Xu, Arik Horne, Miriam Herbert, Anna Drews, Charlotte Thibeault, Moritz Pfeiffer, Stefan Hippenstiel, Andreas Hocke, Holger Müller-Redetzky, Katrin-Moira Heim, Felix Machleidt, Alexander Uhrig, Laure Bosquillon de Jarcy, Linda Jürgens, Miriam Stegemann, Christoph R. Glsenkamp, Hans-Dieter Volk, Christine Goffinet, Markus Landthaler, Emanuel Wyler, Philipp Georg, Maria Schneider, Chantip Dang-Heine, Nick Neuwinger, Kai Kappert, Rudolf Tauber, Victor Corman, Jan Raabe, Kim Melanie Kaiser, Michael To Vinh, Gereon Rieke, Christian Meisel, Thomas Ulas, Matthias Becker, Robert Geffers, Martin Witzenrath, Christian Drosten, Norbert Suttorp, Christof von Kalle, Florian Kurth, Kristian Hndler, Joachim L. Schultze, Anna C. Aschenbrenner, Yang Li, Jacob Nattermann

Issue&Volume: 2020-08-05

Abstract: Coronavirus Disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progresses to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19, associated with increased neutrophil counts and dysregulated immune responses, remains unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole blood and peripheral blood mononuclear cells to determine changes in immune cell composition and activation in mild vs. severe COVID-19 (242 samples from 109 individuals) over time. HLA-DRhiCD11chi inflammatory monocytes with an interferon-stimulated gene signature were elevated in mild COVID-19. Severe COVID-19 was marked by occurrence of neutrophil precursors, as evidence of emergency myelopoiesis, dysfunctional mature neutrophils, and HLA-DRlo monocytes. Our study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and it reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.

DOI: 10.1016/j.cell.2020.08.001

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)30992-2

期刊信息
Cell:《细胞》,创刊于1974年。隶属于细胞出版社,最新IF:36.216
官方网址:https://www.cell.com/