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科学家研发热稳定的COVID-19 mRNA疫苗
作者：小柯机器人 发布时间：2020/7/26 20:16:16

中国军事医学科学院研究人员合作研发热稳定的COVID-19 mRNA候选疫苗。2020年7月23日，《细胞》在线发表了这一项研究成果。

研究人员开发了脂质纳米颗粒包裹的mRNA（mRNA-LNP），这些mRNA编码SARS-CoV-2的受体结合域（RBD），可作为候选疫苗（被称为ARCoV）。肌内免疫ARCoV mRNA-LNP在小鼠和非人类灵长类动物中引发了针对SARS-CoV-2的强大中和抗体以及Th1偏向的细胞反应。对小鼠进行两次剂量的ARCoV免疫可完全抵抗SARS-CoV-2小鼠适应株的攻击。另外，ARCoV以液体制剂生产，可以在室温下保存至少一周。
 
目前研究人员正在1期临床试验中评估这种新型COVID-19 mRNA疫苗ARCoV。
 
据悉，由于持续不断的SARS-CoV-2大流行，目前迫切需要针对COVID-19的疫苗。在所有方法中，基于信使RNA（mRNA）的疫苗已经成为一种快速、多功能的平台，可以应对这一挑战。
 
附：英文原文

Title: A thermostable mRNA vaccine against COVID-19

Author: Na-Na Zhang, Xiao-Feng Li, Yong-Qiang Deng, Hui Zhao, Yi-Jiao Huang, Guan Yang, Wei-Jin Huang, Peng Gao, Chao Zhou, Rong-Rong Zhang, Yan Guo, Shi-Hui Sun, Hang Fan, Shu-Long Zu, Qi Chen, Qi He, Tian-Shu Cao, Xing-Yao Huang, Hong-Ying Qiu, Jian-Hui Nie, Yuhang Jiang, Hua-Yuan Yan, Qing Ye, Xia Zhong, Xia-Lin Xue, Zhen-Yu Zha, Dongsheng Zhou, Xiao Yang, You-Chun Wang, Bo Ying, Cheng-Feng Qin

Issue&Volume: 2020-07-23

Abstract: There has been an urgent need of vaccines against coronavirus disease 2019 (COVID-19) due to the ongoing SARS-CoV-2 pandemic. Among all approaches, messenger RNA (mRNA) -based vaccine has emerged as a rapid and versatile platform to quickly respond to such a challenge. Here, we developed a lipid-nanoparticle-encapsulated mRNA (mRNA-LNP) encoding the receptor binding domain (RBD) of SARS-CoV-2 as a vaccine candidate (termed ARCoV). Intramuscular immunization of ARCoV mRNA-LNPs elicited robust neutralizing antibodies against SARS-CoV-2 as well as Th1-biased cellular response in mice and non-human primates. Two doses of ARCoV immunization in mice conferred complete protection against the challenge of a SARS-CoV-2 mouse adapted strain. Additionally, ARCoV was manufactured in liquid formulation and can be stored at room temperature for at least one week. This novel COVID-19 mRNA vaccine, ARCoV, is currently being evaluated in phase 1 clinical trials.

DOI: 10.1016/j.cell.2020.07.024

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)30932-6

期刊信息
Cell：《细胞》，创刊于1974年。隶属于细胞出版社，最新IF：36.216
官方网址：https://www.cell.com/