德国哥廷根大学Stefan Pöhlmann、Markus Hoffmann等研究人员合作发现，氯喹无法抑制SARS-CoV-2感染人肺细胞。相关论文于2020年7月22日在线发表在《自然》杂志上。
Title: Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2
Author: Markus Hoffmann, Kirstin Msbauer, Heike Hofmann-Winkler, Artur Kaul, Hannah Kleine-Weber, Nadine Krger, Nils C. Gassen, Marcel A. Mller, Christian Drosten, Stefan Phlmann
Abstract: The COVID-19 pandemic, which is caused by the novel coronavirus SARS-CoV-2, has been associated with more than 470,000 fatal cases worldwide. In order to develop antiviral interventions quickly, drugs used for treatment of unrelated diseases are currently being repurposed to combat COVID-19. Chloroquine is a anti-malaria drug that is frequently employed for COVID-19 treatment since it inhibits SARS-CoV-2 spread in the kidney-derived cell line Vero1–3. Here, we show that engineered expression of TMPRSS2, a cellular protease that activates SARS-CoV-2 for entry into lung cells4, renders SARS-CoV-2 infection of Vero cells insensitive to chloroquine. Moreover, we report that chloroquine does not block SARS-CoV-2 infection of the TMPRSS2-positive lung cell line Calu-3. These results indicate that chloroquine targets a pathway for viral activation that is not operative in lung cells and is unlikely to protect against SARS-CoV-2 spread in and between patients.