巴西坎皮纳斯大学Pedro Manoel M. Moraes-Vieira研究小组发现,单核细胞糖酵解升高促进新冠病毒(SARS-CoV-2)感染。该项研究成果于2020年7月17日在线发表在《细胞—代谢》杂志上。
Title: Elevated glucose levels favor SARS-CoV-2 infection and monocyte response through a HIF-1α/glycolysis dependent axis
Author: Ana Campos Codo, Gustavo Gasto Davanzo, Lauar de Brito Monteiro, Gabriela Fabiano de Souza, Stéfanie Primon Muraro, Joo Victor Virgilio-da-Silva, Juliana Silveira Prodonoff, Victor Corasolla Carregari, Carlos Alberto Oliveira de Biagi Junior, Fernanda Crunfli, Jeffersson Leandro Jimenez Restrepo, Pedro Henrique Vendramini, Guilherme Reis-de-Oliveira, Karina Bispo dos Santos, Daniel Augusto de Toledo Teixeira, Pierina Lorencini Parise, Matheus Cavalheiro Martini, Rafael Elias Marques, Helison R. Carmo, Alexandre Borin, Laís Duro Coimbra, Vinícius O. Boldrini, Natalia S. Brunetti, Andre S. Vieira, Eli Mansour, Raisa G. Ulaf, Ana F. Bernardes, Thyago A. Nunes, Luciana C. Ribeiro, Andre C. Palma, Marcus V. Agrela, Maria Luiza Moretti, Andrei C. Sposito, Fabrício Bíscaro Pereira, Licio Augusto Velloso, Marco Aurélio Ramirez Vinolo, André Damasio, José Luiz Proena-Módena, Robson Francisco Carvalho, Marcelo A. Mori, Daniel Martins-de-Souza, Helder I. Nakaya, Alessandro S. Farias, Pedro Manoel M. Moraes-Vieira
Issue&Volume: 2020-07-17
Abstract: COVID-19 can result in severe lung injury. It remained to be determined why diabetic individuals with uncontrolled glucose levels are more prone to develop the severe form of COVID-19. The molecular mechanism underlying SARS-CoV-2 infection and what determines the onset of the cytokine storm found in severe COVID-19 patients are unknown. Monocytes/macrophages are the most enriched immune cell types in the lungs of COVID-19 patients and appear to have a central role in the pathogenicity of the disease. These cells adapt their metabolism upon infection and become highly glycolytic, which facilitates SARS-CoV-2 replication. The infection triggers mitochondrial ROS production, which induces stabilization of hypoxia-inducible factor-1α (HIF-1α) and consequently promotes glycolysis. HIF-1α-induced changes in monocyte metabolism by SARS-CoV-2 infection directly inhibit T cell response and reduce epithelial cell survival. Targeting HIF-1ɑ may have great therapeutic potential for the development of novel drugs to treat COVID-19.
DOI: 10.1016/j.cmet.2020.07.007
Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30365-X
Cell Metabolism:《细胞—代谢》,创刊于2005年。隶属于细胞出版社,最新IF:22.415
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