2020年7月15日，美国伊利诺伊大学Krista A. Varady团队在《细胞—代谢》杂志发表论文，揭示了限时进食对肥胖患者体重和心脏健康的影响。
Title: Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity
Author: Sofia Cienfuegos, Kelsey Gabel, Faiza Kalam, Mark Ezpeleta, Eric Wiseman, Vasiliki Pavlou, Shuhao Lin, Manoela Lima Oliveira, Krista A. Varady
Abstract: Time-restricted feeding (TRF) regimens have grown in popularity; however, very fewstudies have examined their weight-loss efficacy. We conducted the first human trial(Clinicaltrials.gov NCT03867773) to compare the effects of two popular forms of TRF(4 and 6 h) on body weight and cardiometabolic risk factors. Adults with obesity wererandomized to 4-h TRF (eating only between 3 and 7 p.m.), 6-h TRF (eating only between1 and 7 p.m.), or a control group (no meal timing restrictions). After 8 weeks, 4-and 6-h TRF produced comparable reductions in body weight (～3%), insulin resistance,and oxidative stress, versus controls. Energy intake was reduced by ～550 kcal/dayin both TRF groups, without calorie counting. These findings suggest that 4- and 6-hTRF induce mild reductions in body weight over 8 weeks and show promise as interventionsfor weight loss. These diets may also improve some aspects of cardiometabolic health.