瑞典哥德堡大学Fredrik Bckhed研究团队揭示出肠道菌群在糖尿病前期以及糖尿病患者体内的改变。该项研究成果于2020年7月10日在线发表在《细胞—代谢》杂志上。

Title: The Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study

Author: Hao Wu, Valentina Tremaroli, Caroline Schmidt, Annika Lundqvist, Lisa M. Olsson, Manuela Krmer, Anders Gummesson, Rosie Perkins, Gran Bergstrm, Fredrik Bckhed

Issue&Volume: 2020-07-10

Abstract: The link between the gut microbiota and type 2 diabetes (T2D) warrants further investigationbecause of known confounding effects from antidiabetic treatment. Here, we profiledthe gut microbiota in a discovery (n = 1,011) and validation (n = 484) cohort comprisingSwedish subjects naive for diabetes treatment and grouped by glycemic status. We observedthat overall gut microbiota composition was altered in groups with impaired glucosetolerance, combined glucose intolerance and T2D, but not in those with impaired fastingglucose. In addition, the abundance of several butyrate producers and functional potentialfor butyrate production were decreased both in prediabetes and T2D groups. Multivariateanalyses and machine learning microbiome models indicated that insulin resistancewas strongly associated with microbial variations. Therefore, our study indicatesthat the gut microbiota represents an important modifiable factor to consider whendeveloping precision medicine approaches for the prevention and/or delay of T2D.

DOI: 10.1016/j.cmet.2020.06.011

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30312-0