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血液因子传递运动对老年人大脑神经发育和认知改善的益处
作者:小柯机器人 发布时间:2020/7/11 23:35:26

美国加州大学Saul A. Villeda小组取得一项新突破。他们发现血液因子传递运动对老年人大脑神经发育和认知改善的益处。2020年7月10,《科学》发表了这一成果。

研究人员发现,运动的老年小鼠血浆中循环血液因子将运动对神经发育和认知的影响转移至成年久坐的小鼠中。研究发现运动后血浆中糖基磷脂酰肌醇(GPI)特异性磷脂酶D1(Gpld1)的血浆浓度增加,并且与衰老小鼠的认知功能改善相关,Gpld1是肝脏产生的GPI降解酶,在活跃、健康老年人的血液中Gpld1浓度增加。

老年小鼠Gpld1的全身性浓度升高可改善相关的再生和认知障碍,这是通过改变GPI锚定底物裂解下游的信号级联实现的。因此,该研究揭示了一个肝脑轴,老年人的血液因子可以通过该轴传递运动的益处。

附:英文原文

Title: Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain

Author: Alana M. Horowitz, Xuelai Fan, Gregor Bieri, Lucas K. Smith, Cesar I. Sanchez-Diaz, Adam B. Schroer, Geraldine Gontier, Kaitlin B. Casaletto, Joel H. Kramer, Katherine E. Williams, Saul A. Villeda

Issue&Volume: 2020/07/10

Abstract: Reversing brain aging may be possible through systemic interventions such as exercise. We found that administration of circulating blood factors in plasma from exercised aged mice transferred the effects of exercise on adult neurogenesis and cognition to sedentary aged mice. Plasma concentrations of glycosylphosphatidylinositol (GPI)–specific phospholipase D1 (Gpld1), a GPI-degrading enzyme derived from liver, were found to increase after exercise and to correlate with improved cognitive function in aged mice, and concentrations of Gpld1 in blood were increased in active, healthy elderly humans. Increasing systemic concentrations of Gpld1 in aged mice ameliorated age-related regenerative and cognitive impairments by altering signaling cascades downstream of GPI-anchored substrate cleavage. We thus identify a liver-to-brain axis by which blood factors can transfer the benefits of exercise in old age.

DOI: 10.1126/science.aaw2622

Source: https://science.sciencemag.org/content/369/6500/167

期刊信息
Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037