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FGF21激活腹内侧下丘脑谷氨酸能神经元来抑制碳水化合物摄入
作者:小柯机器人 发布时间:2020/7/10 11:58:49

美国爱荷华大学Matthew J. Potthoff、丹麦哥本哈根大学Matthew P. Gillum等研究人员合作发现,FGF21激活腹内侧下丘脑谷氨酸能神经元来抑制碳水化合物的摄入。该项研究成果于2020年7月7日在线发表在《细胞—代谢》杂志上。

研究人员确定了下丘脑中的FGF21靶细胞,并揭示了激活谷氨酸能神经元的FGF21信号是介导FGF21诱导的糖抑制和甜味偏好的必要和充分条件。此外,研究人员表明FGF21直接在腹侧下丘脑(VMH)中发挥作用,从而专门调节蔗糖的摄入量,而不是非营养性甜味偏好、体重或能量消耗。
 
最后,这些数据表明FGF21通过增加VMH中神经元的激活和兴奋性来影响神经元活动。因此,向VMH谷氨酸能神经元传递信号的FGF21是神经回路中调节蔗糖摄入的重要组成部分。
 
据了解,FGF21是肝脏产生的一种内分泌激素,可调节营养和代谢稳态。当大量营养素失衡时,FGF21的产生会增加,并向大脑发出信号以抑制糖的摄入和甜味偏好。但是,介导这些作用的中枢靶标尚不清楚。
 
附:英文原文

Title: FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake

Author: Sharon O. Jensen-Cody, Kyle H. Flippo, Kristin E. Claflin, Yavuz Yavuz, Sarah A. Sapouckey, Grant C. Walters, Yuriy M. Usachev, Deniz Atasoy, Matthew P. Gillum, Matthew J. Potthoff

Issue&Volume: 2020-07-07

Abstract: Fibroblast growth factor 21 (FGF21) is an endocrine hormone produced by the liverthat regulates nutrient and metabolic homeostasis. FGF21 production is increased inresponse to macronutrient imbalance and signals to the brain to suppress sugar intakeand sweet-taste preference. However, the central targets mediating these effects havebeen unclear. Here, we identify FGF21 target cells in the hypothalamus and revealthat FGF21 signaling to glutamatergic neurons is both necessary and sufficient tomediate FGF21-induced sugar suppression and sweet-taste preference. Moreover, we showthat FGF21 acts directly in the ventromedial hypothalamus (VMH) to specifically regulatesucrose intake, but not non-nutritive sweet-taste preference, body weight, or energyexpenditure. Finally, our data demonstrate that FGF21 affects neuronal activity byincreasing activation and excitability of neurons in the VMH. Thus, FGF21 signalingto glutamatergic neurons in the VMH is an important component of the neurocircuitrythat functions to regulate sucrose intake.

DOI: 10.1016/j.cmet.2020.06.008

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30309-0

期刊信息

Cell Metabolism:《细胞—代谢》,创刊于2005年。隶属于细胞出版社,最新IF:22.415
官方网址:https://www.cell.com/cell-metabolism/home
投稿链接:https://www.editorialmanager.com/cell-metabolism/default.aspx