TFH是一种独特的CD4 + T细胞类型，对于大多数抗体和B淋巴细胞反应都是必不可少的。TFH细胞的正常和异常调控与多种疾病有关。Bcl-6是通过谱系确定的TFH细胞转录因子，其活性对于TFH细胞的分化和功能至关重要。
Title: Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits
Author: Jinyong Choi, Huitian Diao, Caterina E. Faliti, Jacquelyn Truong, Meghan Rossi, Simon Blanger, Bingfei Yu, Ananda W. Goldrath, Matthew E. Pipkin, Shane Crotty
Abstract: T follicular helper (TFH) cells are a distinct type of CD4+ T cells that are essential for most antibody and B lymphocyte responses. TFH cell regulation and dysregulation is involved in a range of diseases. Bcl-6 is the lineage-defining transcription factor of TFH cells and its activity is essential for TFH cell differentiation and function. However, how Bcl-6 controls TFH biology has largely remained unclear, at least in part due to the intrinsic challenges of connecting repressors to gene upregulation in complex cell types with multiple possible differentiation fates. Multiple competing models were tested here by a series of experimental approaches to determine that Bcl-6 exhibits negative autoregulation and controls pleiotropic attributes of TFH differentiation and function, including migration, costimulation, inhibitory receptors and cytokines, via multiple repressor-of-repressor gene circuits. Bcl-6 is the signature transcription factor for TFH cells. Crotty and colleagues provide a comprehensive transcriptional map depicting the regulatory circuitry controlled by Bcl-6 in determining TFH cell fate and function.