美国斯坦福大学医学院Michael P. Snyder、Francois Haddad等研究人员合作报道了急性运动后分子层面的全身改变。相关论文于2020年5月28日发表在《细胞》杂志上。
Title: Molecular Choreography of Acute Exercise
Author: Kévin Contrepois, Si Wu, Kegan J. Moneghetti, Daniel Hornburg, Sara Ahadi, Ming-Shian Tsai, Ahmed A. Metwally, Eric Wei, Brittany Lee-McMullen, Jeniffer V. Quijada, Songjie Chen, Jeffrey W. Christle, Mathew Ellenberger, Brunilda Balliu, Shalina Taylor, Matthew G. Durrant, David A. Knowles, Hani Choudhry, Melanie Ashland, Amir Bahmani, Brooke Enslen, Myriam Amsallem, Yukari Kobayashi, Monika Avina, Dalia Perelman, Sophia Miryam Schüssler-Fiorenza Rose, Wenyu Zhou, Euan A. Ashley, Stephen B. Montgomery, Hassan Chaib, Francois Haddad, Michael P. Snyder
Issue&Volume: 2020/05/28
Abstract: Acute physical activity leads to several changes in metabolic, cardiovascular, andimmune pathways. Although studies have examined selected changes in these pathways,the system-wide molecular response to an acute bout of exercise has not been fullycharacterized. We performed longitudinal multi-omic profiling of plasma and peripheralblood mononuclear cells including metabolome, lipidome, immunome, proteome, and transcriptomefrom 36 well-characterized volunteers, before and after a controlled bout of symptom-limitedexercise. Time-series analysis revealed thousands of molecular changes and an orchestratedchoreography of biological processes involving energy metabolism, oxidative stress,inflammation, tissue repair, and growth factor response, as well as regulatory pathways.Most of these processes were dampened and some were reversed in insulin-resistantparticipants. Finally, we discovered biological pathways involved in cardiopulmonaryexercise response and developed prediction models revealing potential resting blood-basedbiomarkers of peak oxygen consumption.
DOI: 10.1016/j.cell.2020.04.043
Source: https://www.cell.com/cell/fulltext/S0092-8674(20)30508-0