瑞士洛桑大学Johanna A. Joyce研究小组通过绘制脑肿瘤微环境图谱揭示出疾病特异性免疫细胞改变。这一研究成果于2020年5月28日在线发表于《细胞》。
Title: Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells
Author: Florian Klemm, Roeltje R. Maas, Robert L. Bowman, Mara Kornete, Klara Soukup, Sina Nassiri, Jean-Philippe Brouland, Christine A. Iacobuzio-Donahue, Cameron Brennan, Viviane Tabar, Philip H. Gutin, Roy T. Daniel, Monika E. Hegi, Johanna A. Joyce
Issue&Volume: 2020-05-28
Abstract: Brain malignancies encompass a range of primary and metastatic cancers, includinglow-grade and high-grade gliomas and brain metastases (BrMs) originating from diverseextracranial tumors. Our understanding of the brain tumor microenvironment (TME) remainslimited, and it is unknown whether it is sculpted differentially by primary versusmetastatic disease. We therefore comprehensively analyzed the brain TME landscapevia flow cytometry, RNA sequencing, protein arrays, culture assays, and spatial tissuecharacterization. This revealed disease-specific enrichment of immune cells with pronounceddifferences in proportional abundance of tissue-resident microglia, infiltrating monocyte-derivedmacrophages, neutrophils, and T cells. These integrated analyses also uncovered multifacetedimmune cell activation within brain malignancies entailing converging transcriptionaltrajectories while maintaining disease- and cell-type-specific programs. Given theinterest in developing TME-targeted therapies for brain malignancies, this comprehensiveresource of the immune landscape offers insights into possible strategies to overcometumor-supporting TME properties and instead harness the TME to fight cancer.
DOI: 10.1016/j.cell.2020.05.007
Source: https://www.cell.com/cell/fulltext/S0092-8674(20)30569-9