德国马克斯普朗克研究所Wieland B. Huttner、Michael Heide等研究人员合作发现，人类特异性ARHGAP11B在胎狨中增加灵长类新皮层的大小和折叠。2020年6月18日，《科学》杂志在线发表了这项成果。
Title: Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset
Author: Michael Heide, Christiane Haffner, Ayako Murayama, Yoko Kurotaki, Haruka Shinohara, Hideyuki Okano, Erika Sasaki, Wieland B. Huttner
Abstract: Abstract The neocortex has expanded during mammalian evolution. Overexpression studies in developing mouse and ferret neocortex have implicated the human-specific gene ARHGAP11B in neocortical expansion, but the relevance for primate evolution has been unclear. Here, we provide functional evidence that ARHGAP11B causes expansion of the primate neocortex. ARHGAP11B expressed in fetal neocortex of the common marmoset under control of the gene’s own, human, promoter increased numbers of basal radial glia progenitors in the marmoset outer subventricular zone, increased numbers of upper-layer neurons, enlarged the neocortex, and induced its folding. Thus, the human-specific ARHGAP11B drives changes in development in the non-human primate marmoset that reflect the changes in evolution that characterize human neocortical development.