美国加州大学旧金山Matthew F. Krummel小组发现，肿瘤抗原利用突触传播在树突状细胞之间转移。该研究于2020年6月8日发表于《癌细胞》。

Title: Visualizing Synaptic Transfer of Tumor Antigens among Dendritic Cells

Author: Megan K. Ruhland, Edward W. Roberts, En Cai, Adriana M. Mujal, Kyle Marchuk, Casey Beppler, David Nam, Nina K. Serwas, Mikhail Binnewies, Matthew F. Krummel

Issue&Volume: 2020/06/08

Abstract: Generation of tumor-infiltrating lymphocytes begins when tumor antigens reach thelymph node (LN) to stimulate T cells, yet we know little of how tumor material isdisseminated among the large variety of antigen-presenting dendritic cell (DC) subsetsin the LN. Here, we demonstrate that tumor proteins are carried to the LN within discretevesicles inside DCs and are then transferred among DC subsets. A synapse is formedbetween interacting DCs and vesicle transfer takes place in the absence of free exosomes.DCs -containing vesicles can uniquely activate T cells, whereas DCs lacking them donot. Understanding this restricted sharing of tumor identity provides substantialroom for engineering better anti-tumor immunity.

DOI: 10.1016/j.ccell.2020.05.002

Source: https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30219-1