以色列魏茨曼科学研究所Keren Levanon研究团队在研究中取得进展。他们发现人类肿瘤微生物组由特定肿瘤类型的细胞内细菌组成。该研究于2020年5月29日发表于《科学》。
他们对肿瘤微生物组进行了全面分析，研究了7种癌症类型（包括乳腺癌、肺癌、卵巢癌、卵巢癌、胰腺癌、黑素瘤癌、骨癌和脑癌）中的1526种肿瘤及其邻近的正常组织。
他们发现每种类型的肿瘤都有独特的微生物组组成，乳腺癌具有特别丰富多样的微生物组。肿瘤内细菌大部分在细胞内，并且存在于癌细胞和免疫细胞中。他们还注意到肿瘤内细菌或其预测功能与肿瘤类型和亚型，患者的吸烟状况以及对免疫疗法的反应之间的相关性。
据悉，细菌是在100多年前在人类肿瘤中首次发现的，但由于其生物量低，肿瘤微生物组的表征仍然具有挑战性。
附：英文原文
Title: The human tumor microbiome is composed of tumor type–specific intracellular bacteria
Author: Deborah Nejman, Ilana Livyatan, Garold Fuks, Nancy Gavert, Yaara Zwang, Leore T. Geller, Aviva Rotter-Maskowitz, Roi Weiser, Giuseppe Mallel, Elinor Gigi, Arnon Meltser, Gavin M. Douglas, Iris Kamer, Vancheswaran Gopalakrishnan, Tali Dadosh, Smadar Levin-Zaidman, Sofia Avnet, Tehila Atlan, Zachary A. Cooper, Reetakshi Arora, Alexandria P. Cogdill, Md Abdul Wadud Khan, Gabriel Ologun, Yuval Bussi, Adina Weinberger, Maya Lotan-Pompan, Ofra Golani, Gili Perry, Merav Rokah, Keren Bahar-Shany, Elisa A. Rozeman, Christian U. Blank, Anat Ronai, Ron Shaoul, Amnon Amit, Tatiana Dorfman, Ran Kremer, Zvi R. Cohen, Sagi Harnof, Tali Siegal, Einav Yehuda-Shnaidman, Einav Nili Gal-Yam, Hagit Shapira, Nicola Baldini, Morgan G. I. Langille, Alon Ben-Nun, Bella Kaufman, Aviram Nissan, Talia Golan, Maya Dadiani, Keren Levanon
Issue&Volume: 2020/05/29
Abstract: Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, and brain tumors. We found that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome. The intratumor bacteria are mostly intracellular and are present in both cancer and immune cells. We also noted correlations between intratumor bacteria or their predicted functions with tumor types and subtypes, patients’ smoking status, and the response to immunotherapy.
DOI: 10.1126/science.aay9189
Source: https://science.sciencemag.org/content/368/6494/973