英国牛津大学Marian Knight研究小组分析了英国SARS-CoV-2感染住院孕妇的临床特点和结局。2020年6月8日，《英国医学杂志》发表了这项成果。

为了分析英国住院的SARS-CoV-2感染的孕妇队列，确定与感染相关的因素，并描述包括感染传播在内的母婴结局，研究组在英国的194个产科单位进行了一项前瞻性全国人群队列研究。

2020年3月1日至4月14日，共有427名孕妇确诊感染SARS-CoV-2并住院。因确诊SARS-CoV-2感染而入院率为每1000名孕妇中4.9例。在SARS-CoV-2感染的孕妇中，233名（56％）为黑人或其他少数族裔，281名（69％）超重或肥胖，175名（41％）年龄在35岁及以上，145名（34％）先前存在合并症。266名（62%）孕妇分娩或流产；其中196名（73%）足月分娩。住院的41名孕妇（10％）需要呼吸支持，5名孕妇（1％）死亡。265名婴儿中有12名（5％）SARS-CoV-2 RNA检测呈阳性，其中6名在出生后12小时内接受了检测。

总之，大多数因SARS-CoV-2感染入院的孕妇为孕中期或孕晚期，多数患者预后良好，SARS-CoV-2向婴儿的传播并不常见。

附：英文原文

Title: Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study

Author: Marian Knight, Kathryn Bunch, Nicola Vousden, Edward Morris, Nigel Simpson, Chris Gale, Patrick O’Brien, Maria Quigley, Peter Brocklehurst, Jennifer J Kurinczuk

Issue&Volume: 2020/06/08

Abstract: Objectives To describe a national cohort of pregnant women admitted to hospital with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the UK, identify factors associated with infection, and describe outcomes, including transmission of infection, for mothers and infants.

Design Prospective national population based cohort study using the UK Obstetric Surveillance System (UKOSS).

Setting All 194 obstetric units in the UK.

Participants 427 pregnant women admitted to hospital with confirmed SARS-CoV-2 infection between 1 March 2020 and 14 April 2020.

Main outcome measures Incidence of maternal hospital admission and infant infection. Rates of maternal death, level 3 critical care unit admission, fetal loss, caesarean birth, preterm birth, stillbirth, early neonatal death, and neonatal unit admission.

Results The estimated incidence of admission to hospital with confirmed SARS-CoV-2 infection in pregnancy was 4.9 (95% confidence interval 4.5 to 5.4) per 1000 maternities. 233 (56%) pregnant women admitted to hospital with SARS-CoV-2 infection in pregnancy were from black or other ethnic minority groups, 281 (69%) were overweight or obese, 175 (41%) were aged 35 or over, and 145 (34%) had pre-existing comorbidities. 266 (62%) women gave birth or had a pregnancy loss; 196 (73%) gave birth at term. Forty one (10%) women admitted to hospital needed respiratory support, and five (1%) women died. Twelve (5%) of 265 infants tested positive for SARS-CoV-2 RNA, six of them within the first 12 hours after birth.

Conclusions Most pregnant women admitted to hospital with SARS-CoV-2 infection were in the late second or third trimester, supporting guidance for continued social distancing measures in later pregnancy. Most had good outcomes, and transmission of SARS-CoV-2 to infants was uncommon. The high proportion of women from black or minority ethnic groups admitted with infection needs urgent investigation and explanation.

DOI: 10.1136/bmj.m2107

Source: https://www.bmj.com/content/369/bmj.m2107