近日，清华大学医学院院长董晨教授、北京市垂杨柳医院副院长陈方教授、中国人民解放军军事医学科学院秦成峰教授等研究人员，合作在新冠病毒康复患者体内检测了特异性体液和细胞免疫。该项研究成果于2020年5月1日在线发表于《免疫》杂志。

Title: Detection of SARS-CoV-2-specific humoral and cellular immunity in COVID-19 convalescent individuals

Author: Ling Ni, Fang Ye, Meng-Li Cheng, Yu Feng, Yong-Qiang Deng, Hui Zhao, Peng Wei, Jiwan Ge, Mengting Gou, Xiaoli Li, Lin Sun, Tianshu Cao, Pengzhi Wang, Chao Zhou, Rongrong Zhang, Peng Liang, Han Guo, Xinquan Wang, Cheng-Feng Qin, Fang Chen, Chen Dong

Issue&Volume: 2020-05-03

Abstract: The World Health Organization has declared SARS-CoV-2 virus outbreak a world-widepandemic. However, there is very limited understanding on the immune responses, especiallyadaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19patients who have recently become virus-free and therefore were discharged, and detectedSARS-CoV-2-specific humoral and cellular immunity in 8 newly discharged patients.Follow-up analysis on another cohort of 6 patients 2 weeks post discharge also revealedhigh titers of IgG antibodies. In all 14 patients tested, 13 displayed serum neutralizingactivities in a pseudotype entry assay. Notably, there was a strong correlation betweenneutralization antibody titers and the numbers of virus-specific T cells. Our workprovides a basis for further analysis of protective immunity to SARS-CoV-2, and understandingthe pathogenesis of COVID-19, especially in the severe cases. It has also implications in developing an effective vaccine to SARS-CoV-2 infection.

DOI: 10.1016/j.immuni.2020.04.023

Source: https://www.cell.com/immunity/fulltext/S1074-7613(20)30181-3