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研究揭示前额小白蛋白在规则转移学习过程中的功能
作者:小柯机器人 发布时间:2020/5/27 14:19:46

美国加州大学Vikaas S. Sohal小组的最新研究,揭示了前额小白蛋白(PV)中间神经元之间的跨半球γ同步在规则转移学习过程中支持行为适应。相关论文于2020年5月25日发表在《自然—神经科学》杂志上。

研究人员探究了PV中枢神经元之间的伽马频率(~40 Hz)同步在小鼠中的作用,该小鼠学习了多种新的提示-奖赏机制。当小鼠接受反馈而先前学习的关联不再有效时,电压指示器显示PV中神经元之间跨半球γ同步的细胞类型特异性增加。

通过传递异相的光遗传学刺激破坏这种同步时,会导致小鼠对过时关联表现出持久性;而同相刺激或其他频率的异相刺激则无法再现这种效果。当新的关联使用以前与行为结果无关的熟悉线索,而不是当关联涉及新线索或颠倒先前学习的关联时,特别需要伽玛同步。因此,伽马同步对于重新评估外部线索行为的显著性必不可少。

据悉,个体必须学习新的策略以适应不断变化的环境。不同神经元中的活动通常表现出同步性,可以动态增强其交流,并可能创建灵活的大脑状态,从而促进行为变化。

附:英文原文

Title: Cross-hemispheric gamma synchrony between prefrontal parvalbumin interneurons supports behavioral adaptation during rule shift learning

Author: Kathleen K. A. Cho, Thomas J. Davidson, Guy Bouvier, Jesse D. Marshall, Mark J. Schnitzer, Vikaas S. Sohal

Issue&Volume: 2020-05-25

Abstract: Organisms must learn new strategies to adapt to changing environments. Activity in different neurons often exhibits synchronization that can dynamically enhance their communication and might create flexible brain states that facilitate changes in behavior. We studied the role of gamma-frequency (~40Hz) synchrony between prefrontal parvalbumin (PV) interneurons in mice learning multiple new cue–reward associations. Voltage indicators revealed cell-type-specific increases of cross-hemispheric gamma synchrony between PV interneurons when mice received feedback that previously learned associations were no longer valid. Disrupting this synchronization by delivering out-of-phase optogenetic stimulation caused mice to perseverate on outdated associations, an effect not reproduced by in-phase stimulation or out-of-phase stimulation at other frequencies. Gamma synchrony was specifically required when new associations used familiar cues that were previously irrelevant to behavioral outcomes, not when associations involved new cues or for reversing previously learned associations. Thus, gamma synchrony is indispensable for reappraising the behavioral salience of external cues.

DOI: 10.1038/s41593-020-0647-1

Source: https://www.nature.com/articles/s41593-020-0647-1

期刊信息

Nature Neuroscience:《自然—神经科学》,创刊于1998年。隶属于施普林格·自然出版集团,最新if:21.126
官方网址:https://www.nature.com/neuro/
投稿链接:https://mts-nn.nature.com/cgi-bin/main.plex