美国加州大学圣迭戈分校Ananda W. Goldrath、Kyla D. Omilusik等研究人员合作发现，感染和恶性肿瘤会引起组织驻留CD8+T细胞的异质性。这一研究成果发表在2020年5月19日出版的《免疫》上。
Title: Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy
Author: J. Justin Milner, Clara Toma, Zhaoren He, Nadia S. Kurd, Quynh P. Nguyen, Bryan McDonald, Lauren Quezada, Christella E. Widjaja, Deborah A. Witherden, John T. Crowl, Laura A. Shaw, Gene W. Yeo, John T. Chang, Kyla D. Omilusik, Ananda W. Goldrath
Abstract: Tissue-resident memory CD8+ T cells (Trm) provide host protection through continuous surveillance of non-lymphoidtissues. Using single-cell RNA-sequencing (scRNA-seq) and genetic reporter mice, weidentified discrete lineages of intestinal antigen-specific CD8+ T cells, including a Blimp1hiId3lo tissue-resident effector cell population most prominent in the early phase of acuteviral and bacterial infections and a molecularly distinct Blimp1loId3hi tissue-resident memory population that subsequently accumulated at later infectiontime points. These Trm populations exhibited distinct cytokine production, secondarymemory potential, and transcriptional programs including differential roles for transcriptionalregulators Blimp1, T-bet, Id2, and Id3 in supporting and maintaining intestinal Trm.Extending our analysis to malignant tissue, we also identified discrete populationsof effector-like and memory-like CD8+ T cell populations with tissue-resident gene-expression signatures that shared featuresof terminally exhausted and progenitor-exhausted T cells, respectively. Our findingsprovide insight into the development and functional heterogeneity of Trm cells, whichhas implications for enhancing vaccination and immunotherapy approaches.