美国麻省理工学院Kwanghun Chung研究小组开发出新技术可使得组织高度弹性化。相关论文于2020年5月18日在线发表在《自然—方法学》杂志上。

研究人员开发了纠缠连接增强型可拉伸组织水凝胶（ELAST），该技术可将组织转变为弹性水凝胶，以同时增强大分子的可及性和机械稳定性。弹性组织具有高度的可拉伸性和可压缩性，可实现可逆的形状转换，并通过机械变薄将探针更快地递送到完整的组织样本中。

这个通用平台可以促进大规模生物系统（例如人体器官）的快速和可扩展的分子表型分析。

附：英文原文

Title: Elasticizing tissues for reversible shape transformation and accelerated molecular labeling

Author: Taeyun Ku, Webster Guan, Nicholas B. Evans, Chang Ho Sohn, Alexandre Albanese, Joon-Goon Kim, Matthew P. Frosch, Kwanghun Chung

Issue&Volume: 2020-05-18

Abstract: We developed entangled link-augmented stretchable tissue-hydrogel (ELAST), a technology that transforms tissues into elastic hydrogels to enhance macromolecular accessibility and mechanical stability simultaneously. ELASTicized tissues are highly stretchable and compressible, which enables reversible shape transformation and faster delivery of probes into intact tissue specimens via mechanical thinning. This universal platform may facilitate rapid and scalable molecular phenotyping of large-scale biological systems, such as human organs.

DOI: 10.1038/s41592-020-0823-y

Source: https://www.nature.com/articles/s41592-020-0823-y