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宿主对新冠病毒的响应失衡驱动COVID-19的进展
作者:小柯机器人 发布时间:2020/5/18 13:13:23

美国西奈山伊坎医学院Benjamin R. tenOever、Randy A. Albrecht、Jean K. Lim等研究人员合作发现,宿主对新冠病毒(SARS-CoV-2)的响应失衡驱动了COVID-19的进展。2020年5月15日,《细胞》在线发表了这一成果。

研究人员提供了SARS-CoV-2转录应答的深入分析并与其他呼吸道病毒进行了比对。除了COVID-19患者的转录和血清分析外,SARS-CoV-2感染的细胞和动物模型还表现出独特的炎症反应。这种反应为:低水平的I型和III型干扰素、趋化因子升高,以及IL-6高表达。
 
研究人员认为,固有的抗病毒防御能力降低,以及大量炎性细胞因子产生是COVID-19的特征。
 
附:英文原文

Title: Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Author: Daniel Blanco-Melo, Benjamin E. Nilsson-Payant, Wen-Chun Liu, Skyler Uhl, Daisy Hoagland, Rasmus Mller, Tristan X. Jordan, Kohei Oishi, Maryline Panis, David Sachs, Taia T. Wang, Robert E. Schwartz, Jean K. Lim, Randy A. Albrecht, Benjamin R. tenOever

Issue&Volume: 2020-05-15

Abstract: Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information regarding viral behavior and host response following SARS-CoV-2 infection. Here we offer an in-depth analysis of the transcriptional response to SARS-CoV-2 compared with other respiratory viruses. Cell and animal models of SARS-CoV-2 infection, in addition to transcriptional and serum profiling of COVID-19 patients, consistently revealed a unique and inappropriate inflammatory response. This response is defined by low levels of type I and III interferons juxtaposed to elevated chemokines and high expression of IL-6. We propose that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.

DOI: 10.1016/j.cell.2020.04.026

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)30489-X

期刊信息
Cell:《细胞》,创刊于1974年。隶属于细胞出版社,最新IF:36.216
官方网址:https://www.cell.com/