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疟原虫的血液阶段循环驱动器
作者:小柯机器人 发布时间:2020/5/17 23:59:05

美国杜克大学Steven B. Haase研究组取得新进展。他们发现固有振荡器驱动恶性疟原虫的血液阶段循环。相关论文于2020515日发表于《科学》。

他们在体外培养系统中鉴定了恶性疟原虫的周期,并表明该疟原虫具有与昼夜节律和细胞周期振荡器相关的分子标记。所鉴定的四个菌株中的每个菌株都有不同的周期,这表明应控制菌株的固有周期。最后,他们证明了疟原虫在循环周期内具有较低的细胞间差异,与昼夜节律振荡器相当。他们得出的结论是,固有振荡器可以维持疟原虫的节律性生命周期。

研究人员表示,恶性疟原虫感染的血液阶段显示48小时的发育周期,最终导致疟原虫从红细胞同步释放,从而触发宿主的48小时发烧周期。该周期可以由宿主昼夜节律过程或疟原虫固有振荡器外在驱动。

附:英文原文

Title: An intrinsic oscillator drives the blood stage cycle of the malaria parasite Plasmodium falciparum

Author: Lauren M. Smith, Francis C. Motta, Garima Chopra, J. Kathleen Moch, Robert R. Nerem, Bree Cummins, Kimberly E. Roche, Christina M. Kelliher, Adam R. Leman, John Harer, Tomas Gedeon, Norman C. Waters, Steven B. Haase

Issue&Volume: 2020/05/15

Abstract: The blood stage of the infection of the malaria parasite Plasmodium falciparum exhibits a 48-hour developmental cycle that culminates in the synchronous release of parasites from red blood cells, which triggers 48-hour fever cycles in the host. This cycle could be driven extrinsically by host circadian processes or by a parasite-intrinsic oscillator. To distinguish between these hypotheses, we examine the P. falciparum cycle in an in vitro culture system and show that the parasite has molecular signatures associated with circadian and cell cycle oscillators. Each of the four strains examined has a different period, which indicates strain-intrinsic period control. Finally, we demonstrate that parasites have low cell-to-cell variance in cycle period, on par with a circadian oscillator. We conclude that an intrinsic oscillator maintains Plasmodium’s rhythmic life cycle.

DOI: 10.1126/science.aba4357

Source: https://science.sciencemag.org/content/368/6492/754

期刊信息
Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037