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中国科学家报道首个灭活新冠候选疫苗的动物实验结果
作者:小柯机器人 发布时间:2020/5/8 20:34:17

近日,中国医学科学院秦川、浙江省疾控中心张严峻、科兴控股生物技术有限公司Weidong Yin、中国科学院生物物理研究所王祥喜、中国食品药品检定研究院Changgui Li、中国疾控中心Jinxing Lu等研究人员合作报道了首个新冠病毒(SARS-CoV-2)灭活候选疫苗的动物实验结果。该研究于2020年5月6日在线发表于《科学》。

研究人员开发了纯化的灭活SARS-CoV-2病毒候选疫苗(PiCoVacc)的中试规模生产,该疫苗可在小鼠、大鼠和非人类灵长类动物中诱导SARS-CoV-2特异性中和抗体。这些抗体中和了10个代表性SARS-CoV-2菌株,表明可能对SARS-CoV-2菌株具有更广泛的中和能力。
 
使用两种不同剂量(每剂3μg或6μg)进行的三种免疫分别在猕猴中提供了针对SARS-CoV-2攻击的部分或完全保护,而没有明显的抗体依赖性感染增强。这些数据支持针对人类SARS-CoV-2疫苗的进一步临床开发。
 
附:英文原文

Title: Rapid development of an inactivated vaccine candidate for SARS-CoV-2

Author: Qiang Gao, Linlin Bao, Haiyan Mao, Lin Wang, Kangwei Xu, Minnan Yang, Yajing Li, Ling Zhu, Nan Wang, Zhe Lv, Hong Gao, Xiaoqin Ge, Biao Kan, Yaling Hu, Jiangning Liu, Fang Cai, Deyu Jiang, Yanhui Yin, Chengfeng Qin, Jing Li, Xuejie Gong, Xiuyu Lou, Wen Shi, Dongdong Wu, Hengming Zhang, Lang Zhu, Wei Deng, Yurong Li, Jinxing Lu, Changgui Li, Xiangxi Wang, Weidong Yin, Yanjun Zhang, Chuan Qin

Issue&Volume: 2020/05/06

Abstract: Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) has resulted in an unprecedented public health crisis. There are currently no SARS-CoV-2-specific treatments or vaccines available due to the novelty of the virus. Hence, rapid development of effective vaccines against SARS-CoV-2 are urgently needed. Here we developed a pilot-scale production of a purified inactivated SARS-CoV-2 virus vaccine candidate (PiCoVacc), which induced SARS-CoV-2-specific neutralizing antibodies in mice, rats and non-human primates. These antibodies neutralized 10 representative SARS-CoV-2 strains, suggesting a possible broader neutralizing ability against SARS-CoV-2 strains. Three immunizations using two different doses (3 μg or 6 μg per dose) provided partial or complete protection in macaques against SARS-CoV-2 challenge, respectively, without observable antibody-dependent enhancement of infection. These data support clinical development of SARS-CoV-2 vaccines for humans.

DOI: 10.1126/science.abc1932

Source: https://science.sciencemag.org/content/early/2020/05/05/science.abc1932

期刊信息
Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037